Links Between Iron and Lipids: Implications in Some Major Human Diseases.
Links Between Iron and Lipids: Implications in Some Major Human Diseases.
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DOI：
10.3390/ph11040113
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发表时间：
2018-10-22
期刊：
影响因子：
--
通讯作者：
Nanjundan M
中科院分区：
文献类型：
--
作者：
Rockfield S;Chhabra R;Robertson M;Rehman N;Bisht R;Nanjundan M
维持铁稳态对细胞健康至关重要，因为其过量和不足都是有害的。同样，作为细胞膜和信号传导介质的重要组成部分的脂质也必须受到严格调控，以阻止疾病进展。最近的研究，使用了无数的模式生物，以及来自临床研究的数据，揭示了这两种代谢途径之间的联系，但这些相互作用背后的机制以及它们在人类疾病进展中的作用仍不清楚。在这篇综述中，我们总结了文献描述铁和脂质途径之间的串扰，包括胆固醇，鞘脂和脂滴代谢的改变，以响应铁水平的变化。我们讨论了与铁和脂质改变相关的人类疾病，包括神经退行性疾病，以及铁如何促进疾病发病机制的潜在机制。最后，我们回顾了有关铁还原技术及其在治疗这些衰弱性疾病患者中的治疗潜力的研究。我们认为铁介导的脂质代谢途径的改变参与了这些疾病的进展，但还需要进一步的研究来阐明所涉及的机制。
Maintenance of iron homeostasis is critical to cellular health as both its excess and insufficiency are detrimental. Likewise, lipids, which are essential components of cellular membranes and signaling mediators, must also be tightly regulated to hinder disease progression. Recent research, using a myriad of model organisms, as well as data from clinical studies, has revealed links between these two metabolic pathways, but the mechanisms behind these interactions and the role these have in the progression of human diseases remains unclear. In this review, we summarize literature describing cross-talk between iron and lipid pathways, including alterations in cholesterol, sphingolipid, and lipid droplet metabolism in response to changes in iron levels. We discuss human diseases correlating with both iron and lipid alterations, including neurodegenerative disorders, and the available evidence regarding the potential mechanisms underlying how iron may promote disease pathogenesis. Finally, we review research regarding iron reduction techniques and their therapeutic potential in treating patients with these debilitating conditions. We propose that iron-mediated alterations in lipid metabolic pathways are involved in the progression of these diseases, but further research is direly needed to elucidate the mechanisms involved.
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