Regulation of angiogenesis by phospholipid lysophosphatidic acid
Regulation of angiogenesis by phospholipid lysophosphatidic acid
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DOI：
10.2741/4148
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发表时间：
2013-06-01
影响因子：
3.1
通讯作者：
Ren, Bin
中科院分区：
文献类型：
--
作者：
Chen, Yiliang;Ramakrishnan, Devi Prasadh;Ren, Bin
溶血磷脂酸（LPA）作为一种具有生物活性的磷脂信号介质，正逐渐成为内皮细胞功能和血管生成的重要调节因子。许多研究表明，LPA在调节内皮细胞迁移、增殖和分化过程中起着积极的作用，这些过程在血管生成中都是必不可少的。LPA通过调节血管生成相关基因的表达，促进病理性血管生成。有趣的是，LPA介导的血管生成信号机制与特定的g蛋白偶联受体和下游MAPK相关，包括Erk1/2、p38和JNK、蛋白激酶D （PKD-1）、Rho激酶（ROCK）和NF-kappa B信号通路。LPA通过复杂的信号网络调控血管生成反应，LPA信号被整合并转导到细胞核，协调不同血管生成基因的转录。这些机制的研究将为内皮细胞生物学和血管生成程序的理解提供新的和有价值的见解。这些知识将有助于设计更好的治疗缺血性心血管疾病和恶性肿瘤的方法。
Lysophosphatidic acid (LPA) as a bioactive phospholipid signaling mediator is emerging as an important regulator of endothelial cell functions and angiogenesis. Many studies have shown that LPA is an active player in regulating the processes of endothelial cell migration, proliferation, and differentiation, all essential in angiogenesis. Through modulating angiogenesis associated gene expression, LPA also promotes pathological angiogenesis. Intriguingly, the angiogenic signaling mechanisms mediated by LPA have been linked to specific G-protein coupled receptors and down stream MAPK including Erk1/2, p38 and JNK, protein kinase D (PKD-1), Rho kinase (ROCK), and the NF-kappa B signaling pathways. LPA regulates angiogenic responses via a complex signaling network, and LPA signaling is integrated and transduced to the nucleus to coordinate the transcription of different angiogenic genes. Investigation of these mechanisms will provide novel and valuable insights into the understanding of endothelial cell biology and angiogenic programs. This knowledge will facilitate designs for better therapies for the ischemic cardiovascular diseases and malignant tumors.