Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantation.
Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantation.
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DOI：
10.3389/fimmu.2014.00555
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发表时间：
2014
影响因子：
7.3
通讯作者：
Smyth LA
中科院分区：
文献类型：
--
作者：
Agarwal A;Fanelli G;Letizia M;Tung SL;Boardman D;Lechler R;Lombardi G;Smyth LA
外来体是由身体的许多细胞释放的细胞外囊泡。这些小囊泡在局部环境和全身的细胞间通讯中起重要作用，促进蛋白质、细胞因子以及miRNA在细胞之间的转移。从免疫细胞如树突状细胞（DC）中分离的外泌体调节免疫应答的观察结果为这些结构被认为是潜在的免疫抑制剂铺平了道路。事实上，使用DC衍生的外泌体促进对特定癌症抗原的免疫应答的临床试验现在正在进行中。外泌体也可以对免疫应答具有负面影响，并且从调节性T细胞（Tcells）和T细胞的其他亚群分离的外泌体已经显示具有免疫抑制能力。在这里，我们回顾了目前已知的Treg衍生的外泌体及其对免疫调节的贡献，并强调了其预防移植排斥反应的可能治疗潜力，并用作评估移植结果的诊断工具。
Exosomes are extracellular vesicles released by many cells of the body. These small vesicles play an important part in intercellular communication both in the local environment and systemically, facilitating in the transfer of proteins, cytokines as well as miRNA between cells. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has paved the way for these structures to be considered as potential immunotherapeutic reagents. Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. Exosomes can also have a negative effect on the immune response and exosomes isolated from regulatory T cells (Tregs) and other subsets of T cells have been shown to have immune suppressive capacities. Here, we review what is currently known about Treg derived exosomes and their contribution to immune regulation, as well as highlighting their possible therapeutic potential for preventing graft rejection, and use as diagnostic tools to assess transplant outcome.
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DOI：
10.1038/mt.2008.1
发表时间：
2008-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dai S;Wei D;Wu Z;Zhou X;Wei X;Huang H;Li G
通讯作者：
Li G
影响因子：
12.4
作者：
Kim, SH;Bianco, N;Robbins, PD
通讯作者：
Robbins, PD
影响因子：
16
作者：
Crescitelli R;Lässer C;Szabó TG;Kittel A;Eldh M;Dianzani I;Buzás EI;Lötvall J
通讯作者：
Lötvall J
影响因子：
4
作者：
Harris VK;Sadiq SA
通讯作者：
Sadiq SA
激活的 T 细胞外泌体通过 Fas 信号通路促进肿瘤侵袭
影响因子：
4.4
作者：
Cai, Zhijian;Yang, Fei;Wang, Jianli
通讯作者：
Wang, Jianli