EFFECT OF INUTERO COCAINE EXPOSURE ON STARTLE AND ITS MODIFICATION
EFFECT OF INUTERO COCAINE EXPOSURE ON STARTLE AND ITS MODIFICATION
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DOI：
10.1159/000480959
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发表时间：
1989-01-01
期刊：
影响因子：
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通讯作者：
LEITNER, DS
中科院分区：
文献类型：
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作者：
ANDAY, EK;COHEN, ME;LEITNER, DS
使用反射矫正程序评估了产前可卡因对母亲滥用可卡因(C暴露)所生婴儿的听觉感觉神经反应的影响。使用受控的眨眼轻拍对眉间进行反射矫正测试，无论是单独呈现还是以90分贝的SPL音调呈现。将19名接触碳的婴儿的结果与19名健康的匹配的非药物婴儿进行比较。两组婴儿的方差比较显示，接触C的婴儿总体上反应更强，表现为更大的眉间反射，对听觉刺激更敏感，表现为伴随敲击的音调增加的眨眼(p<；0.05)。这些数据表明，在宫内接触可卡因可能会对感觉神经加工产生直接影响，并可能使这些婴儿面临认知和/或神经后遗症的风险。
The effect of prenatal cocaine on acoustic sensorineural reactivity was assessed using reflex modification procedures in infants born to mothers with cocaine abuse (C-exposed). Reflex modification was tested using a controlled eyeblink-eliciting tap to the glabella presented either alone or with a 90-dB SPL tone. The results from 19 C-exposed infants were compared to 19 healthy matched drug-free infants. ANOVA comparison of the two groups showed C-exposed infants were more reactive in general, as indicated by a larger glabellar reflex, and more responsive to auditory stimuli, as indicated by an increased blink when the tone accompanied the tap (p < 0.05). These data suggest that in utero cocaine exposure may have a direct effect on sensorineural processing and may place these infants at risk for cognitive and/or neurological sequelae.