Heritability estimates for dental caries and sucrose sweetness preference
Heritability estimates for dental caries and sucrose sweetness preference
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DOI：
10.1016/j.archoralbio.2006.06.003
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发表时间：
2006-12-01
影响因子：
3
通讯作者：
Hart, Thomas C.
中科院分区：
文献类型：
--
作者：
Bretz, Walter A.;Corby, Patricia M. A.;Hart, Thomas C.
目的：这项研究的目的是确定龋齿特征和蔗糖甜度偏好的遗传力估计。设计：参与者包括115对4-7岁的双胞胎。龋病检查遵循NIDCR标准，其中病变的严重程度也被确定。双胞胎们用脸部标尺对五种浓度的蔗糖/葡萄汁溶液(0.15-1.17M)的偏好进行了排名。提交分析的变量：(1)表面型龋患率(SBCPR)；(2)病变严重程度指数(LSI)；(3)蔗糖甜度偏好评分(SSPS)。结果：调整了年龄和性别的遗传度估计为：SBCPR-h(2)=64.6(p<；.00001)，LSI-h(2)=61.7(p<；.00001)和SSPS-h(2)=55.2(p<；.00001)。在SBCPR和LSI模型中，将SPSS作为协变量没有进行遗传度估计。结论：这些结果表明龋病性状的变异和蔗糖甜度偏好有显著的遗传贡献，且是独立中介的。(C)2006爱思唯尔有限公司。保留所有权利。
Objective: The aim of this study was to determine heritability estimates for dental caries traits and sucrose sweetness preference.Design: Participants included 115 pairs of twins 4-7-years-old. Caries exams followed NIDCR criteria where the severity of the lesion was also determined. Twins ranked their preference for five concentrations of sucrose/grape juice solutions (0.15-1.17 M) with a Face Scale. Variables submitted to analysis: (1) surface-based caries prevalence rate (SBCPR); (2) lesion severity index (LSI); (3) sucrose sweetness preference score (SSPS). Heritability analyses were performed with the SOLAR software package.Results: Heritability estimates adjusted for age and gender were: SBCPR - h(2) = 64.6 (p < .00001), LSI - h(2) = 61.7 (p < .00001) and SSPS - h(2) = 55.2 (p < .00001). Treating SPSS as a covariate in the SBCPR and LSI models did not after heritability estimates.Conclusions: These results suggest that variation in dental caries traits and sucrose sweetness preference have a significant genetic contribution that is mediated independently. (c) 2006 Elsevier Ltd. All rights reserved.