Controlled release niosome embedded chitosan system: effect of crosslink mesh dimensions on drug release.
Controlled release niosome embedded chitosan system: effect of crosslink mesh dimensions on drug release.
复制标题
控释类脂质体嵌入壳聚糖系统：交联网格尺寸对药物释放的影响。
DOI：
10.1002/jbm.a.34275
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Alcantar,Norma
中科院分区：
文献类型：
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作者：
Williams,EvaChristabel;Toomey,Ryan;Alcantar,Norma
我们报告了一种模型化疗药物递送系统，该系统包括包装在温度敏感性壳聚糖网络内的非离子表面活性剂囊泡（囊泡）。这种智能包装或包装系统中的包装提供了两个明显的优势。首先，凝胶阻止了类囊泡的循环，并保持在肿瘤附近的递送。其次，壳聚糖网络保护囊泡免受张力波动的影响，张力波动影响递送速率。张力是能够施加跨膜渗透力的溶质浓度的总和。所有释放速率实验均使用荧光染料5，6-羧基荧光素进行。从单独的裸囊泡和囊泡包埋的壳聚糖网络监测释放速率。据观察，壳聚糖网络在低离子强度环境和类似于肿瘤部位的pH条件下将递送从100小时延长至55天。壳聚糖的主要作用是增加对释放时间和剂量的控制，并通过防止囊泡不受控制地破裂的高离子强度环境来稳定囊泡。次要因素包括壳聚糖网络的交联密度、单个壳聚糖聚合物的分子量、囊泡内的染料浓度和包装在壳聚糖网络内的囊泡的数密度。这些因素中的每一个都可以改变以微调释放速率。© 2012 Wiley Periodicals，Inc. J Biomed Mater Res Part A 100 A：3296 - 3303，2012.
We report on a model chemotherapy drug delivery system comprising nonionic surfactant vesicles (niosomes) packaged within a temperature‐sensitive chitosan network. This smart packaging, or package‐within‐a package system, provides two distinct advantages. First, the gel prevents circulation of the niosomes and maintains delivery in the vicinity of a tumor. Second, the chitosan network protects the niosomes against fluctuations in tonicity, which affects delivery rates. Tonicity is the sum of the concentrations of the solutes which have the capacity to exert an osmotic force across the membrane. All release rate experiments were conducted with 5,6‐carboxyfluorescein, a fluorescent dye. Release rates were monitored from both bare niosomes alone and niosome‐embedded, chitosan networks. It was observed that chitosan networks prolonged delivery from 100 h to 55 days in low ionic strength environment and pH conditions similar to a tumor site. The primary effect of chitosan is to add control on release time and dosage, and stabilize the niosomes through a high ionic strength surrounding that prevents uncontrolled bursting of the niosomes. Secondary factors include crosslink density of the chitosan network, molecular weight of the individual chitosan polymers, dye concentration within the niosomes, and the number density of niosomes packaged within the chitosan network. Each of these factors can be altered to fine‐tune release rates. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:3296–3303, 2012.