Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder.
Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder.
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DOI：
10.1002/brb3.711
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发表时间：
2017-06
影响因子：
3.1
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Cui X;Niu W;Kong L;He M;Jiang K;Chen S;Zhong A;Li W;Lu J;Zhang L
世界卫生组织表示，全世界每年有近100万人自杀，其中40%的自杀者患有抑郁症。本研究的主要目的是探讨外周血单个核细胞（PBMCs）长链非编码rna （lncRNAs）表达与重度抑郁症（MDD）患者自杀风险之间的关系。使用人类LncRNA 3.0微阵列分析，包括30,586人LncRNA和RT - PCR，鉴定出6个下调的LncRNA在MDD患者中差异表达。根据自杀意念和自杀企图，将重度抑郁症患者的自杀风险分为有自杀意念组和无自杀意念组，有自杀企图组和无自杀企图组。RT - PCR检测MDD患者和对照组中6种lncrna的表达。6种lncrna的表达在无自杀意念、有自杀意念和对照组之间存在显著差异；与自杀企图相关的lncrna在没有自杀企图、有自杀企图和对照组之间存在显著差异。与对照组相比，只有自杀意念组和自杀未遂组lncrna表达明显下降。本研究提示6种下调lncrna的表达与MDD患者的自杀风险呈负相关，pbmc中lncrna的表达可能有助于临床医生判断MDD患者的自杀风险，及时提供治疗，预防自杀。
WHO stated that nearly one million people commit suicide every year worldly, and 40% of the suicide completer suffered from depression. The primary aim of this study was to explore the association between long noncoding RNAs (lncRNAs) expression in peripheral blood mononuclear cells (PBMCs) and suicide risk of patients with major depressive disorder (MDD). Using Human LncRNA 3.0 microarray profiling which includes 30,586 human lncRNAs and RT‐PCR, six down‐regulated lncRNAs were identified differentially expressed in MDD patients. According to suicidal ideation and suicidal attempt, the suicide risk of MDD patients was classified into suicidal ideation versus no suicidal ideation groups, and past attempt versus no past attempt groups, respectively. The expression of six lncRNAs in MDD patients and controls were examined by RT‐PCR. The expression of six lncRNAs had significant differences between no suicidal ideation, suicidal ideation, and controls; corresponding lncRNAs associated with suicidal attempt had remarkable differences between no past attempt, past attempt, and controls. Additionally, only the expression of lncRNAs in suicidal ideation group and past attempt group markedly declined compared with controls. This study indicated that the expression of six down‐regulated lncRNAs had a negative association with suicide risk in MDD patients, and the expression of lncRNAs in PBMCs could have the potential to help clinician judge the suicide risk of MDD patients to provide timely treatment and prevent suicide.