The histone database:: A comprehensive resource for histones and histone fold-containing proteins
The histone database:: A comprehensive resource for histones and histone fold-containing proteins
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DOI：
10.1002/prot.20814
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发表时间：
2006-03-01
影响因子：
2.9
通讯作者：
Landsman, D
中科院分区：
文献类型：
--
作者：
Mari単o-Ramirez, L;Hsu, B;Landsman, D
组蛋白数据库是一个精心策划且可搜索的组蛋白和包含组蛋白样折叠的非组蛋白的全长序列和结构的集合，由主要公共数据库编译而成。几种新的组蛋白折叠蛋白已被鉴定，包括亨廷顿蛋白相互作用蛋白 HYPM。此外，根据最近的七少之子蛋白的晶体结构，提出了组蛋白折叠结构域的序列分析的解释。该数据库包含来自总共 975 个生物体的四种核心组蛋白（H2A、H2B、H3 和 H4）和接头组蛋白 (H1/H5) 的多重序列比对的更新集合。该数据库还包含有关人类组蛋白基因补体的信息，并提供组蛋白和含组蛋白折叠蛋白的三维结构的链接。组蛋白数据库是用于研究组蛋白和含组蛋白折叠蛋白的结构和功能的综合生物信息学资源。该数据库可从 http://research.nhgri.nih.gov/histones/ 获取。
TheThe Histone Database is a curated and searchable collection of full-length sequences and structures of histones and nonhistone proteins containing histone-like folds, compiled from major public databases. Several new histone fold-containing proteins have been identified, including the huntingtin-interacting protein HYPM. Additionally, based on the recent crystal structure of the Son of Sevenless protein, an interpretation of the sequence analysis of the histone fold domain is presented. The database contains an updated collection of multiple sequence alignments for the four core histones (H2A, H2B, H3, and H4) and the linker histones (H1/H5) from a total of 975 organisms. The database also contains information on the human histone gene complement and provides links to three-dimensional structures of histone and histone fold-containing proteins. The Histone Database is a comprehensive bioinformatics resource for the study of structure and function of histones and histone fold-containing proteins. The database is available at http://research.nhgri.nih.gov/histones/.