Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation
Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation
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DOI：
10.1182/blood-2002-12-3789
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发表时间：
2003-09-01
期刊：
影响因子：
20.3
通讯作者：
Martinelli, G
中科院分区：
文献类型：
--
作者：
Soverini, S;Cavo, M;Martinelli, G
我们使用了一种灵敏的实时逆转录聚合酶链反应检测来定量诊断时收集的74例新诊断的多发性骨髓瘤（MM）患者的骨髓样本中细胞周期蛋白D1 mRNA水平，这些患者随机接受单或双自体外周血干细胞移植作为其恶性肿瘤一线治疗的一部分。在46例病例中，进行荧光原位杂交（FISH）分析和/或常规细胞遗传学检测11号染色体异常。t（11;14）或11三体患者细胞周期蛋白D1显著过表达（P
We used a sensitive real-time reverse transcription-polymerase chain reaction assay to quantify cyclin D1 mRNA levels in bone marrow samples collected at diagnosis from 74 newly diagnosed multiple myeloma (MM) patients who were randomized to undergo either single or double autologous peripheral blood, stem cell transplantation as part of first-line therapy for their malignancy. In 46 cases, fluorescence in situ hybridization (FISH) analysis and/or conventional cytogenetics were performed to detect chromosome 11 abnormalities. Patients with the t(11;14) or trisomy 11 significantly overexpressed cyclin D1 (P