Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review.
Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review.
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三种微小RNA基因多态性与宫颈癌风险的关联：荟萃分析和系统评价
DOI：
10.1186/s12957-021-02463-4
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发表时间：
2021-12-16
影响因子：
3.2
通讯作者：
Xia T
中科院分区：
文献类型：
--
作者：
Xu J;Geng J;Zhang Q;Fan Y;Qi Z;Xia T
目的从人乳头瘤病毒（HPV）感染的流行程度和宫颈癌的发展情况来看，宿主细胞上微rna （miRNA）单核苷酸多态性（SNP）的调控可能是影响宫颈癌发生的重要因素之一。为了探讨miRNA多态性在宫颈癌发生发展中的作用，我们进行了一项分析研究。方法选取了3个被广泛研究的mirna （miRNA-146a rs2910164、miRNA-499 rs3746444和miRNA-196a2 rs11614913）的多态性。然后，我们进行了一项荟萃分析（首次）来调查他们对宫颈癌的易感性。通过检索Pubmed、the Cochrane Library、Embase、CBM、CNKI、万方数据库和VIP数据库，对这3种mirna与宫颈癌易感性的相关性进行病例对照研究。记录基本特征，并使用STATA 15.1软件对病例研究进行meta分析。结果miRNA-146a rs2910164突变在隐性模型（OR = 0.804, 95% CI = 0.652-0.992，P= 0.042; CC vs CG+GG）和等位基因模型（OR = 0.845, 95% CI = 0.721-0.991，P= 0.038; C vs G）中均显著降低宫颈癌的发生风险。miRNA-499 rs3746444与宫颈癌发生风险无显著相关性。microrna - 196 a2 rs11614913突变能显著降低子宫颈癌的风险在纯合模型(OR = 0.641, 95% CI -0.919 = 0.447, P = 0.016; TT和CC),占主导地位的模式(OR = 0.795, 95% CI -0.994 = 0.636, P = 0.045; CT + TT和CC),隐性模型(OR = 0.698, 95% CI -0.917 = 0.532, P = 0.01; TT和CC + CT),和等位基因模型(OR = 0.783, 95% CI -0.954 = 0.643, P = 0.015, T和C)。综上所述，本荟萃分析显示miRNA-146a rs2910164和miRNA-196a2 rs11614913突变基因型与宫颈癌风险降低相关。因此，它们可能是预防宫颈癌的两个基因调控点。系统评审注册号prospero注册号CRD42021270079。
ObjectiveRegulation of single nucleotide polymorphisms (SNP) in micro-RNA (miRNA) on the host cells may be one of the most important factors influencing the occurrence of cervical cancer based on the prevalence of HPV infection and the development of cervical cancer. In order to explore the contribution of miRNA polymorphism to the occurrence and development of cervical cancer, we conducted an analytical study.MethodsWe selected the polymorphisms of three widely studied miRNAs (miRNA-146a rs2910164, miRNA-499 rs3746444, and miRNA-196a2 rs11614913). Then, we conducted a meta-analysis (for the first time) to investigate their susceptibility to cervical cancer. Case control studies on the correlation between these three miRNAs and cervical cancer susceptibility were investigated by searching on from Pubmed, The Cochrane Library, Embase, CBM, CNKI, Wanfang database, and VIP database. Basic characteristics were recorded and meta-analysis of the case studies was performed using the STATA 15.1 software.ResultsThe miRNA-146a rs2910164 mutation significantly reduced the risk of cervical cancer in both recessive model (OR = 0.804, 95% CI = 0.652-0.992,P= 0.042; CC vs. CG+GG) and allelic model (OR = 0.845, 95% CI = 0.721-0.991,P= 0.038; C vs. G). There was no significant correlation between miRNA-499 rs3746444 and the risk of cervical cancer. The miRNA-196a2 rs11614913 mutation was significantly associated with a reduced risk of cervical cancer in homozygous model (OR = 0.641, 95% CI = 0.447-0.919,P= 0.016; TT vs. CC), dominant model (OR = 0.795, 95% CI = 0.636-0.994,P= 0.045; CT+TT vs. CC), recessive model (OR = 0.698, 95% CI = 0.532-0.917,P= 0.01; TT vs. CC+CT), and allelic models (OR = 0.783, 95% CI = 0.643-0.954,P= 0.015, T vs. C).ConclusionIn summary, this meta-analysis shows that the mutant genotypes of miRNA-146a rs2910164 and miRNA-196a2 rs11614913 are associated with a reduced risk of cervical cancer. Therefore, they may be two gene regulatory points for the prevention of cervical cancer.Systematic review registrationPROSPERO registration number CRD42021270079.
影响因子：
3.2
作者：
Lee H;Kim KR;Cho NH;Hong SR;Jeong H;Kwon SY;Park KH;An HJ;Kim TH;Kim I;Yoon HK;Suh KS;Min KO;Choi HJ;Park JY;Yoo CW;Lee YS;Lee HJ;Lee WS;Park CS;Lee Y;Gynecological Pathology Study Group of the Korean Society of Pathologists
通讯作者：
Gynecological Pathology Study Group of the Korean Society of Pathologists