A new murine model to study the pathogenesis of tuberculous meningitis
A new murine model to study the pathogenesis of tuberculous meningitis
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DOI：
10.1086/511273
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发表时间：
2007-03-01
影响因子：
6.4
通讯作者：
van Furth, A. Marceline
中科院分区：
文献类型：
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作者：
van Well, Gijs Th. J.;Wieland, Catharina W.;van Furth, A. Marceline
结核性脑膜炎（TM）是结核病的一种严重并发症，主要发生在儿童时期。没有小鼠模型可用于研究这种疾病。本研究的目的是建立一个小鼠模型，以探讨TM的发病机制。小鼠脑内注射结核分枝杆菌。从脑匀浆中可以培养出杆菌，并且在组织病理学检查中，发现所有小鼠都有脑膜细胞浸润。我们发现单核吞噬细胞和嗜中性粒细胞的化学引诱物水平升高。这是TM的第一个小鼠模型，可用于研究宿主对TM的反应，特别是先天免疫反应。
Tuberculous meningitis ( TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response.