Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.
Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.
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DOI：
10.1186/s13058-015-0601-4
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发表时间：
2015-07-16
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影响因子：
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通讯作者：
Dorgan JF
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作者：
Bertrand KA;Baer HJ;Orav EJ;Klifa C;Shepherd JA;Van Horn L;Snetselaar L;Stevens VJ;Hylton NM;Dorgan JF
儿童期和青少年期超重和肥胖与乳腺癌风险降低相关，与成人体重指数（BMI）无关。这些关联可能通过乳腺密度介导。我们前瞻性地研究了182名儿童饮食干预研究（DISC）中年龄在25-29岁的女性在随访时的早期身体肥胖与通过MRI测量的成人乳房密度的关系。身高、体重和其他因素在基线（8-10岁）和青春期的年度门诊访视时进行测量。我们使用线性混合效应模型来量化25-29岁的乳腺密度百分比和致密和非致密乳腺体积与特定年龄的青年体重指数（BMI）Z分数四分位数的相关性，调整临床，治疗组，当前成人BMI和其他公认的乳腺癌风险因素和乳腺密度预测因子。我们观察到在所有青年诊所就诊的年龄特异性BMI Z评分与乳腺密度百分比之间存在负相关，并对当前成人BMI和其他协变量进行了调整（所有p值均<0.01）。基线BMI Z评分在调整当前成人BMI和其他协变量后，与处于底部四分位数的患者相比，处于顶部四分位数的患者（8-10岁）的成人乳腺密度显著较低[最小二乘均值（LSM）：23.4%; 95%置信区间（CI）：18.0%，28.8%]（LSM：31.8%; 95%CI：25.2%，38.4%）（p趋势<0.01）。还观察到绝对致密乳腺体积的显著负相关性（所有p值<0.01），而与非致密乳腺体积没有明确的相关性。这些结果支持这一假设，即儿童和青少年时期的身体肥胖可能在绝经前乳腺密度中发挥重要作用，独立于当前的BMI，并进一步表明对绝对致密乳腺体积的直接或间接影响。NCT 00458588; 2007年4月9日本文的在线版本（doi：10.1186/s13058-015-0601-4）包含补充材料，可供授权用户使用。
Overweight and obesity in childhood and adolescence are associated with reduced breast cancer risk, independent of adult body mass index (BMI). These associations may be mediated through breast density. We prospectively examined associations of early life body fatness with adult breast density measured by MRI in 182 women in the Dietary Intervention Study in Children (DISC) who were ages 25–29 at follow-up. Height, weight, and other factors were measured at baseline (ages 8–10) and annual clinic visits through adolescence. We used linear mixed-effects models to quantify associations of percent breast density and dense and non-dense breast volume at ages 25–29 with quartiles of age-specific youth body mass index (BMI) Z-scores, adjusting for clinic, treatment group, current adult BMI, and other well-established risk factors for breast cancer and predictors of breast density. We observed inverse associations between age-specific BMI Z-scores at all youth clinic visits and percent breast density, adjusting for current adult BMI and other covariates (all p values <0.01). Women whose baseline BMI Z-scores (at ages 8–10 years) were in the top quartile had significantly lower adult breast density, after adjusting for current adult BMI and other covariates [least squares mean (LSM): 23.4 %; 95 % confidence interval (CI): 18.0 %, 28.8 %] compared to those in the bottom quartile (LSM: 31.8 %; 95 % CI: 25.2 %, 38.4 %) (p trend <0.01). Significant inverse associations were also observed for absolute dense breast volume (all p values <0.01), whereas there were no clear associations with non-dense breast volume. These results support the hypothesis that body fatness during childhood and adolescence may play an important role in premenopausal breast density, independent of current BMI, and further suggest direct or indirect influences on absolute dense breast volume. NCT00458588; April 9, 2007 The online version of this article (doi:10.1186/s13058-015-0601-4) contains supplementary material, which is available to authorized users.