Therapeutic effect of electroacupuncture in a p75 knockout mouse model of progressive hearing loss.
Therapeutic effect of electroacupuncture in a p75 knockout mouse model of progressive hearing loss.
复制标题
电针对 p75 基因敲除小鼠进行性听力损失模型的治疗作用
DOI：
10.1136/acupmed-2013-010450
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Miyata S.
中科院分区：
文献类型：
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作者：
Maeda T;Taniguchi M;Shingaki K;Kanazawa S;Miyata S.
神经营养因子受体p75（p75 NTR）敲除小鼠（p75（−/−）小鼠）提供了一种良好的进行性听力损失动物模型。1在3月龄的p75（−/−）小鼠中观察到螺旋神经节神经元（SGN）的细胞丢失和耳蜗基底转处的毛细胞变性。此外，从3月龄到6月龄，p75（-/-）小鼠的听阈逐渐升高; 6月龄后，小鼠大多出现听力损失。1以前的几份报告表明，电针（EA）刺激可以改善耳鸣或听力损失的主观症状。2 3然而，EA刺激对听力损失的治疗作用的分子机制仍不清楚。因此，为了确定EA刺激是否有助于预防听力损失，我们使用了p75（−/−）小鼠进行性听力损失模型。定宫（SI 19;小肠19）和翳风（TE 17;三焦经17）是
Neurotrophin receptor p75 (p75NTR) knockout mice (p75 (−/−) mice) provide a good animal model of progressive-onset hearing loss. 1 Cell loss of the spiral ganglion neurons (SGNs) and hair cell degeneration at the basal turn of the cochlea are seen in p75 (−/−) mice from 3 months of age. Furthermore, from 3 to 6months of age, the hearing thresholds of p75 (−/−) mice are gradually raised; and after 6 months of age, the mice mostly exhibit hearing loss. 1 Several previous reports have indicated that electroacupuncture (EA) stimulation may improve subjective symptoms of tinnitus or hearing loss. 2 3 However, the molecular mechanisms underlying the therapeutic effect of EA stimulation for hearing loss remain unclear. Thus, to determine whether EA stimulation is useful for the prevention of hearing loss, we used a p75 (−/−) mouse model of progressive-onset hearing loss. The Ting Gong (SI19; Small Intestine 19) and the Yifeng (TE17; Triple Energiser meridian 17) are