Tracheo-broncho-bronchiolar lesions in Sjogren's syndrome
Tracheo-broncho-bronchiolar lesions in Sjogren's syndrome
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DOI：
10.1111/j.1440-1843.2007.01155.x
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发表时间：
2008-01-01
期刊：
影响因子：
6.9
通讯作者：
Aida, Shinsuke
中科院分区：
文献类型：
--
作者：
Kobayashi, Hideo;Kanoh, Soichiro;Aida, Shinsuke
一名 53 岁女性报告有持续咳嗽和痰中带血的症状。她不吸烟，但被诊断患有干燥综合症。胸部CT显示中叶综合征、支气管扩张和弥漫性小叶中心结节性病变。支气管镜检查显示从软骨环突出的多个白色息肉样病变，并且通过气管支气管壁中骨组织的存在，组织学证实了气管支气管病骨软骨增生。视频辅助胸腔镜活检显示淋巴细胞聚集导致滤泡性支气管细支气管炎。红霉素治疗可以改善滤泡性细支气管炎，但不能改善骨软骨增生性气管支气管病。
A 53-year-old woman reported having a persistent cough and bloody sputum. She did not smoke but had received a diagnosis of Sjogren's syndrome. Chest CT revealed middle lobe syndrome, bronchiectasis and diffuse centrilobular nodular lesions. Bronchoscopy displayed multiple whitish polypoid lesions protruding from the cartilage rings and tracheobronchopathia osteochondroplastica was histologically confirmed by the presence of bony tissue in the tracheo-bronchial wall. Video-assisted thoracoscopic biopsy demonstrated lymphocyte aggregation causing follicular broncho-bronchiolitis. Erythromycin therapy resulted in improvement of the follicular bronchiolitis but not the tracheobronchopathia osteochondroplastica.