Assessment of thoracic spinal cord electrophysiological activity through magnetoneurography
Assessment of thoracic spinal cord electrophysiological activity through magnetoneurography
复制标题
通过神经磁图评估胸脊髓电生理活动
DOI：
10.1016/j.clinph.2021.09.023
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
A. Okawa
中科院分区：
文献类型：
--
作者：
J. Hashimoto;S. Kawabata;Toru Sasaki;Y. Hoshino;K. Sekihara;Y. Adachi;Taishi Watanabe;Y. Miyano;Y. Mitani;Shinji Sato;Sukchan Kim;T. Yoshii;A. Okawa
目的通过磁神经成像无创、详细地显示胸段脊髓的电生理活动。方法采用带超导量子干涉生物磁强计的磁神经成像系统，对5名健康志愿者进行单侧和双侧坐骨神经交替刺激后，胸段脊髓电流周围磁场的测量。通过空间滤波从磁场数据中获得电流分布，并将其叠加在X射线图像上进行可视化。结果同步刺激双侧坐骨神经后，所有受试者均获得了足够高的磁信号强度和信噪比。沿椎管的先导和拖尾成分以及流入除极部位的内向成分上升到上胸椎。全胸椎内向电流传导速度为42.4m/s。结论应用神经磁图可直观显示胸髓的电生理活动，为双侧坐骨神经同步刺激提供了一种新的方法。磁神经造影术有望成为胸椎脊髓病功能评估的一种有用的检查方法。
ObjectiveNoninvasive and detailed visualization of electrophysiological activity in the thoracic spinal cord through magnetoneurography.MethodsIn five healthy volunteers, magnetic fields around current flowing in the thoracic spinal cord after alternating unilateral and synchronized bilateral sciatic nerve stimulation were measured using a magnetoneurograph system with superconductive quantum interference device biomagnetometers. The current distribution was obtained from the magnetic data by spatial filtering and visualized by superimposing it on the X-ray image. Conduction velocity was calculated using the peak latency of the current waveforms.ResultsA sufficiently high magnetic signal intensity and signal-to-noise ratio were obtained in all participants after synchronized bilateral sciatic nerve stimulation. Leading and trailing components along the spinal canal and inward components flowing into the depolarization site ascended to the upper thoracic spine. Conduction velocity of the inward current in the whole thoracic spine was 42.4 m/s.ConclusionsVisualization of electrophysiological activity in the thoracic spinal cord was achieved through magnetoneurography and a new method for synchronized bilateral sciatic nerve stimulation. Magnetoneurography is expected to be a useful modality in functional assessment of thoracic myelopathy.SignificanceThis is the first report to use magnetoneurography to noninvasively visualize electrophysiological activity in the thoracic spinal cord in detail.