The effect of ethanol and diazepam on the fatty acid composition of plasma and liver phospholipids in the rat.
The effect of ethanol and diazepam on the fatty acid composition of plasma and liver phospholipids in the rat.
复制标题
乙醇和地西泮对大鼠血浆和肝脏磷脂脂肪酸组成的影响。
DOI：
10.1248/bpb.18.842
复制
发表时间：
1995
影响因子：
2
通讯作者：
M. Miric
中科院分区：
文献类型：
--
作者：
V. Ristić;S. Vrbaški;Z. Lalić;M. Miric
本研究的主要目的是确定大鼠血浆和肝脏磷脂（PL）中脂肪酸组成的可能变化是由长期饮酒、安定治疗和长期饮酒和安定同时服用引起的。慢性乙醇消耗量（11 g/kg/d）升高了血浆饱和脂肪酸（SFA）和单不饱和脂肪酸（MUFA）的比例，降低了血浆和肝脏PL中最重要的多不饱和脂肪酸（PUFA）的比例。肝脏PL中脂肪酸组成的变化表明乙醇可以改变细胞膜脂质的组成。地西泮（10 mg/kg/d）使血浆PL中SFA和MUFA含量升高，血浆和肝脏PL中22:6n-3二十二碳六烯酸（DHA）含量显著降低，血浆PL脂肪酸组成的变化提示脂肪酸代谢紊乱。乙醇和地西泮联用对大鼠血浆和肝脏脂肪酸含量的影响最大，其中乙醇和地西泮单独作用的影响是综合的，并且乙醇和地西泮的相互作用增强了这种影响。
The main interest of the present study was to determine possible alterations in fatty acid composition in rat plasma and liver phospholipids (PL) caused by chronic ethanol consumption, diazepam treatment and chronic consumption of alcohol and diazepam together. Chronic ethanol consumption (11 g/kg/d) elevated the proportion of plasma saturated (SFA) and mono-unsaturated fatty acids (MUFA), and decreased the most important polyunsaturated fatty acids (PUFA) in plasma and liver PL. The alterations in fatty acid composition in liver PL indicate that ethanol can change the composition of cell membrane lipids. Diazepam treatment (10 mg/kg/d) elevated the contents of SFA and MUFA in plasma PL. On the other hand, diazepam produced a drastic decrease in 22:6n-3 docosahexaenoic acid (DHA) in plasma and liver PL. These changes in plasma PL fatty acid composition indicated a disturbance of fatty acid metabolism. The changes in fatty acid contents of plasma and liver PL were the greatest in rats treated with a combination of ethanol and diazepam, in which there was a summation of the effects of ethanol or diazepam alone, and the effects were intensified by an ethanol-diazepam interaction.