Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk
Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk
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DOI：
10.1016/j.clinbiochem.2006.01.010
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发表时间：
2006-03-01
影响因子：
2.8
通讯作者：
Wong, KS
中科院分区：
文献类型：
--
作者：
Baum, L;Ng, HK;Wong, KS
目的：对氧磷酶（PON1）是一种与高密度脂蛋白（HDL）颗粒相关的酶，可抑制氧化和动脉粥样硬化的形成。我们试图调查PON1 Q192R多态性与中风和心脏病的关联。设计和方法：在一项病例对照研究中，我们对242例缺血性中风，231例心肌梗死（MI）和310例健康对照受试者进行基因分型，所有中国人。吸烟者（OR = 3.1，P = 0.01）、男性或年龄小于60岁的MI患者的RR增加。R+基因型在脑卒中患者中增加，特别是大动脉型（R+的OR=2.6和P=0.02，RR的OR= 1.0）或吸烟者中。中风患者RR的相对缺乏可能是由于高危人群（如吸烟者）的早期MI或死亡。R+基因型在高血压患者（OR = 2.1，P = 0.02）而非血压正常者（OR = 1.0Subjects.Conclusions：PON1192R+基因型与卒中和MI相关，尤其是在患者亚群中，其模式提示可能的存活效应。(C)2006年加拿大临床化学家协会。All rights reserved.
Objectives: Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease.Design and methods: In a case control study, we genotyped 242 ischemic stroke, 231 myocardial infarction (MI), and 310 healthy control subjects, all Chinese.Results: R-containing genotypes (R+) were associated with vascular disease, OR = 1.5, P = 0.03. RR was increased in MI patients who were either smokers (OR = 3.1, P = 0.01), male, or Younger than 60. R+ but not RR genotypes were increased in stroke patients, particularly large artery type(OR=2.6 and P=0.02 for R+,OR= 1.0 for RR) or among smokers. The relative dearth of RR in stroke might be due to earlier MI or death in at-risk people, such as smokers. R+ genotypes were increased with stroke in hypertensive (OR = 2.1, P = 0.02) but not normotensive (OR = 1.0) Subjects.Conclusions: PON1 192R+ genotypes were associated with stroke and MI, particularly in Subsets of patients, in patterns Suggesting a possible survivor effect. (C) 2006 The Canadian Society of Clinical Chemists. All rights reserved.