Vagus nerve recordings: new opportunities to investigate autonomic function in humans.
Vagus nerve recordings: new opportunities to investigate autonomic function in humans.
复制标题
迷走神经记录：研究人类自主功能的新机会。
DOI：
10.1113/jp280300
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Park,Jeanie
中科院分区：
文献类型：
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作者：
Park,Jeanie
在20世纪60年代，Vallbo和Hagbarth建立了显微神经成像技术，其中神经冲动直接记录来自有意识人类的外周神经（Vallbo，2018）。神经电描记术对整合神经生理学领域产生了巨大的影响，使得能够进行广泛的研究来询问感觉传入神经以及针对肌肉（MSNA）和皮肤（SSNA）的传出交感神经的功能。特别是，交感神经的显微神经造影术已经推进了我们对健康和患病人群中循环的神经控制的理解。它已被用来检查交感神经系统（SNS）调节的控制机制，如压力反射，SNS反应的压力，运动升压反射，机制的SNS过度激活慢性疾病，预后价值的MSNA，和性别和种族差异SNS调节举几个例子。重要的是，显微神经造影术为测试靶向药物和非药物干预对患者群体中SNS功能的影响的临床试验增加了有价值的信息。2020年），Ottaviani和同事报告了一个病例系列的第一个神经内记录从颈部迷走神经在人类使用显微神经成像技术。虽然显微神经造影术以前曾用于记录各种周围神经，包括腓神经，尺神经和正中神经，但迷走神经以前从未被靶向，可能是因为它靠近颈内动脉和颈内静脉。目前的研究表明，微电极穿透颈部迷走神经可以在超声引导下安全可行地进行，使用后路，可以在不穿过颈内静脉的情况下进入迷走神经。
In the 1960s, Vallbo and Hagbarth established the microneurography technique in which nerve impulses are recorded directly from a peripheral nerve from conscious humans in realtime (Vallbo, 2018). Microneurography has since had a tremendous impact on the field of integrative neurophysiology, enabling a wide array of studies interrogating the function of sensory afferent nerves, and efferent sympathetic nerves directed to muscle (MSNA) and skin (SSNA). In particular, microneurography of sympathetic nerves has advanced our understanding of the neural control of the circulation in both healthy and diseased populations. It has been used to examine sympathetic nervous system (SNS) regulation by control mechanisms such as baroreflexes, SNS reactivity to stress, the exercise pressor reflex, mechanisms underlying SNS overactivation in chronic disease, prognostic value of MSNA, and sex and race differences in SNS regulation to name a few examples. Importantly, microneurography has added valuable information to clinical trials testing the impact of targeted pharmacologic and nonpharmacologic interventions on SNS function in patient populations.In the current issue of J Physiol (Ottaviani et al., 2020), Ottaviani and colleagues report a case series of the first intraneural recordings from the cervical vagus nerve in humans using the microneurography technique. While microneurography has previously been used to record from various peripheral nerves including the peroneal, ulnar and median nerves, the vagus nerve had never previously been targeted, likely because of its close proximity to the internal carotid artery and internal jugular vein. The current study demonstrates that microelectrode penetration of the cervical vagus nerve can be safely and feasibly performed under ultrasound guidance, using a posterior approach that enables access to the vagus nerve without traversing the internal jugular vein.