Multilocus genotypes, a tree of individuals, and human evolutionary history
Multilocus genotypes, a tree of individuals, and human evolutionary history
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DOI：
10.1086/515510
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发表时间：
1997-09-01
影响因子：
9.8
通讯作者：
CavalliSforza, LL
中科院分区：
文献类型：
--
作者：
Mountain, JL;CavalliSforza, LL
我们的目标是从人类基因数据中推断出人类进化历史的一般模式和细节。在这里，我们提出了在个人层面上的遗传数据的分析结果。从平均75个DNA多态性/个体推断，一个与来自非洲、亚洲、欧洲和大洋洲的12个人类群体的144个个体相关的树是显著的，因为大多数个体与其区域群体的其他成员聚类。为了解释这棵树，我们考虑的因素，影响树的模式，包括遗传位点的数量检查，人口隔离的长度，抽样过程中，和组之间的基因流的程度。了解这些因素的影响使我们能够推断出人类进化史的细节，否则可能无法发现。我们的分析表明，一些最近的祖先（S）的每一个测试的几个人可能已经移民。总的来说，各区域集团内的人口似乎彼此隔离，
Our goal is to infer, from human genetic data, general patterns as well as details of human evolutionary history. Here we present the results of an analysis of genetic data at the level of the individual. A tree relating 144 individuals from 12 human groups of Africa, Asia, Europe, and Oceania, inferred from an average of 75 DNA polymorphisms/individual, is remarkable in that most individuals cluster with other members of their regional group. In order to interpret this tree, we consider the factors that influence the tree pattern, including the number of genetic loci examined, the length of population isolation, the sampling process, and the extent of gene flow among groups. Understanding the impact of these factors enables us to infer details of human evolutionary history that might otherwise remain undetected. Our analyses indicate that some recent ancestor(s) of each of a few of the individuals tested may have immigrated. In general, the populations within regional groups appear to have been isolated from one another for