Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe
Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe
复制标题
DOI：
10.1016/j.neuroimage.2020.117214
复制
发表时间：
2020-11-01
期刊：
影响因子：
5.7
通讯作者：
Fell, J.
中科院分区：
文献类型：
--
作者：
Derner, M.;Dehnen, G.;Fell, J.
内侧颞叶（MTL）结构的电生理活动是陈述性长时记忆的关键。单神经元和微电路的研究结果利用人类微线记录从内侧颞叶仍然是零碎的。特别是，相同或不同的神经元组是否参与不同的记忆功能是一个悬而未决的问题。在这里，我们研究了在人类MTL的类别特异性反应的基础上，在手术前癫痫患者进行联想长期记忆任务的单神经元记录。此外，在编码和提取过程中呈现听觉节拍刺激来调节记忆性能。我们描述了杏仁核，内嗅皮层，海马和海马旁皮层属于不同的反应类的神经元的比例。这些都需要神经元编码刺激熟悉性，神经元编码成功的项目记忆，神经元编码相关的源记忆，以及这些类别之间的重叠。作为主要的结果，我们表明，神经元刺激熟悉（旧/新的效果），即使使用以前已知的，而不是全新的刺激材料（话），可以确定在MTL。我们观察到一个显着的重叠熟悉相关的神经元和神经元编码项目检索（记忆/遗忘效应）。最大比例的熟悉相关的神经元被发现在海马旁皮质，和相当大比例的所有海马旁神经元与成功的项目检索。与成功源检索相关的神经元不同于编码相关信息的神经元。最重要的是，编码项目记忆的神经元和编码相关源记忆的神经元之间没有重叠，这强烈表明这些功能是由不同的神经元组促进的。
Electrophysiological activity in medial temporal lobe (MTL) structures is pivotal for declarative long-term memory. Single-neuron and microcircuit findings capitalizing on human microwire recordings from the medial temporal lobe are still fragmentary. In particular, it is an open question whether identical or different groups of neurons participate in different memory functions. Here, we investigated category-specific responses in the human MTL based on single-neuron recordings in presurgical epilepsy patients performing an associative long-term memory task. Additionally, auditory beat stimuli were presented during encoding and retrieval to modulate memory performance. We describe the proportion of neurons in amygdala, entorhinal cortex, hippocampus and parahippocampal cortex belonging to different response classes. These entail neurons coding stimulus-familiarity, neurons coding successful item memory, and neurons coding associated source memory, as well as the overlap between these classes. As major results we demonstrate that neurons responding to stimulus familiarity (old/new effect) can be identified in the MTL even when using previously known rather than entirely novel stimulus material (words). We observed a significant overlap between familiarity-related neurons and neurons coding item retrieval (remembered/forgotten effect). The largest fraction of familiarity-related neurons was found in the parahippocampal cortex, and a considerable fraction of all parahippocampal neurons was related to successful item retrieval. Neurons related to successful source retrieval were different from the neurons coding the associated information. Most importantly, there was no overlap between neurons coding item memory and those coding associated source memory strongly suggesting that these functions are facilitated by different sets of neurons.