Organophosphonate functionalized Gd@C82 as a magnetic resonance imaging contrast agent
Organophosphonate functionalized Gd@C82 as a magnetic resonance imaging contrast agent
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DOI：
10.1021/cm7023982
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发表时间：
2008-03-25
影响因子：
8.6
通讯作者：
Dennis, T. John S.
中科院分区：
文献类型：
--
作者：
Shu, Chun-Ying;Wang, Chun-Ru;Dennis, T. John S.
采用简单的合成方法，高产率地合成了一种新型的含有机膦官能团的磁共振成像造影剂。在0.35T下，该分子的纵向水质子弛豫率(37.0 mm(-1)S(-1))远高于商用全扫描(Gd-DTPA BMA，5.7 mm(-1)S(-1))。值得注意的是，在相同条件下，该分子的弛豫度大于羧化的Gd@C-82(16.0 mm(-1)S(-1))，表明官能团在图像对比度增强中起着重要作用。此外，引入膦取代基可提供骨靶向磁共振造影剂。
A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM(-1) s(-1)) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM(-1) s(-1)) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C-82 (16.0 mM(-1) s(-1)) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.