Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C).
Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C).
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围产期光周期和儿童期癌症：国际儿童期癌症队列联盟 (I4C) 182,856 名个体的汇总结果。
DOI：
10.1080/07420528.2020.1740724
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发表时间：
2020
影响因子：
2.8
通讯作者：
Cap
中科院分区：
文献类型：
--
作者：
Lewis,Philip;Hellmich,Martin;Fritschi,Lin;Tikellis,Gabriella;Morfeld,Peter;Groß,JValérie;Foster,RussellG;Paltiel,Ora;Klebanoff,MarkA;Golding,Jean;Olsen,Sjurdur;Magnus,Per;Ponsonby,Anne-Louise;Linet,MarthaS;Ward,MaryH;Cap
实验证据表明，围产期光印记的生物钟和系统可能会影响下游的生理和癌症风险在以后的生活。对人类来说，主要的昼夜节律刺激是每日的明暗周期。在此，我们探讨围产期光周期特征（光周期：由一年中的时间和位置决定的日光持续时间）与儿童癌症风险之间的关系。我们使用了国际儿童癌症队列联盟（I4 C）中六个国家（澳大利亚、丹麦、以色列、挪威、英国、美国）的182,856名母亲和婴儿的汇总数据。使用考克斯比例风险回归估计风险比（HR）和95%置信区间（CI）。与预测的差异剂量反应一致，限制性三次样条表明围产期平均每日光周期（0-24 h）和儿童癌症风险之间存在潜在的非线性、非单调关系。在对154，121名仅在8-16小时范围内经历妊娠晚期光周期的个体进行的限制性分析中，妊娠晚期平均每日光周期每增加一小时，患儿童癌症的相对风险降低9%[HR：0.91（95%CI：0.84-0.99）]。总之，在围产期光周期和儿童癌症的第一项研究中，我们检测到在总研究人群的8-16小时组中，妊娠晚期平均每日光周期和儿童癌症风险之间存在反向[“保护性”]线性相关。有限的统计能力阻碍了对暴露于更极端光周期的个人的风险进行调查。未来的研究需要确认差异光周期相关的风险和进一步调查的假设昼夜印记机制是必要的。
Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose–responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0–24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8–16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84–0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [“protective”] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8–16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.