mTOR signaling PLD takes center stage
mTOR signaling PLD takes center stage
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DOI：
10.4161/cc.7.20.6881
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发表时间：
2008-10-15
期刊：
影响因子：
4.3
通讯作者：
Chen, Jie
中科院分区：
文献类型：
--
作者：
Sun, Yuting;Chen, Jie
哺乳动物雷帕霉素靶蛋白（mTOR）组装了一个信号网络，该网络转导营养信号和各种其他刺激以调节广泛的细胞功能。在两种不同的mTOR复合物中，mTORC 1受TSC-Rheb通路的控制，TSC-Rheb通路充当多个上游信号的整合器。还已知涉及磷脂酶D（PLD）和磷脂酸（PA）的脂质信号传导级联介导mTORC 1上游的促有丝分裂信号。一项新的研究揭示了这两种调节途径之间的直接联系，并证明PLD 1是Rheb激活mTORC 1的效应子。PLD作为营养传感器的新作用也被提出。在这个额外的视图中，我们讨论了PA和PLD在mTORC 1信号网络和它所管辖的生物过程中的重要性。我们还考虑了最近几项研究结果的影响，并提出了PLD-mTOR信号转导机制模型，以在不久的将来进行测试。
The mammalian target of rapamycin (mTOR) assembles a signaling network that transduces nutrient signals and various other stimuli to regulate a wide range of cellular functions. Of the two distinct mTOR complexes, mTORC1 is under the control of the TSC-Rheb pathway, which serves as an integrator of multiple upstream signals. A lipid signaling cascade involving phospholipase D (PLD) and phosphatidic acid (PA) has also been known to mediate mitogenic signals upstream of mTORC1. A new study now reveals a direct connection between these two regulatory pathways and demonstrates that PLD1 is an effector of Rheb in the activation of mTORC1. A novel role of PLD as a nutrient sensor has also been suggested. In this extra-view, we discuss the emerging importance of PA and PLD in the mTORC1 signaling network and the biological processes it governs. We also consider the implications from several recent findings and propose mechanistic models of PLD-mTOR signaling to be tested in the near future.