Increased risk of depressive and anxiety disorders in relatives of patients with Parkinson disease
Increased risk of depressive and anxiety disorders in relatives of patients with Parkinson disease
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DOI：
10.1001/archpsyc.64.12.1385
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发表时间：
2007-12-01
影响因子：
--
通讯作者：
Rocca, Walter A.
中科院分区：
文献类型：
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作者：
Arabia, Gennarina;Grossardt, Brandon R.;Rocca, Walter A.
背景：帕金森病（PD）患者的亲属患PD和其他神经系统疾病的风险增加；然而，他们患精神疾病的风险仍不确定。目的：比较PD患者一级亲属与对照组一级亲属发生抑郁、焦虑障碍的风险。设计、环境和参与者：在一项基于人群的历史队列研究中，我们纳入了162名PD患者的1000名一级亲属和147名对照者的850名一级亲属。PD患者和对照组都是明尼苏达州奥姆斯特德县人口的代表。主要结果测量：通过与亲属（或其代理人）的电话访谈和从记录链接系统（家庭研究方法）查阅他们的医疗记录，分别获得每个亲属的精神疾病记录。精神障碍的定义采用DSM-IV的临床标准或常规诊断。结果：我们发现PD患者的一级亲属与对照组的一级亲属相比，几种精神疾病的风险增加(风险比[HR]， 1.54； 95%可信区间[CI]， 1.21-1.95
Context: Relatives of patients with Parkinson disease (PD) have an increased risk of PD and other neurologic disorders; however, their risk of psychiatric disorders remains uncertain.Objective: To study the risk of depressive disorders and anxiety disorders among first-degree relatives of patients with PD compared with first-degree relatives of controls.Design, Setting, and Participants: In a population-based, historical cohort study, we included 1000 first-degree relatives of 162 patients with PD and 850 first-degree relatives of 147 controls. Both patients with PD and controls were representative of the population of Olmsted County, Minnesota.Main Outcome Measures: Documentation of psychiatric disorders was obtained for each relative separately through a combination of telephone interviews with the relatives (or their proxies) and review of their medical records from a records-linkage system (family study method). Psychiatric disorders were defined using clinical criteria from the DSM-IV or routine diagnoses.Results: We found an increased risk of several psychiatric disorders in first-degree relatives of patients with PD compared with first-degree relatives of controls (hazard ratio [HR], 1.54; 95% confidence interval [CI], 1.21-1.95; P