Role of persistent CMV infection in configuring T cell immunity in the elderly.
Role of persistent CMV infection in configuring T cell immunity in the elderly.
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DOI：
10.1186/1742-4933-4-2
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发表时间：
2007-03-21
期刊：
影响因子：
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通讯作者：
Pawelec, Graham
中科院分区：
文献类型：
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作者：
Vasto, Sonya;Colonna-Romano, Giuseppina;Pawelec, Graham
衰老与许多生理参数的下降有关，包括多种免疫系统功能。从中年到80岁左右，由于心血管疾病或癌症而死亡的频率似乎随着年龄的增长而增加，此后趋于稳定。然而，传染病造成的死亡率并没有稳定下来，而是继续无限期地加速上升。老年人通常具有寡克隆扩增的T细胞，特别是CD8细胞，这是令人惊讶的，往往与巨细胞病毒（CMV）血清阳性。这反过来又与T细胞免疫的许多相同的表型和功能改变有关，这些改变被认为是免疫系统衰老的生物标志物。因此，CMV和宿主免疫系统相互作用的方式在确定特异性免疫的“年龄”方面至关重要。因此，我们可以认为免疫衰老在某些方面是一种感染状态。这意味着针对病原体的干预措施可能会改善受影响的器官系统。因此，CMV导向的抗病毒药物或疫苗接种可能对以后的免疫力有有益的影响。
Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems to increase with age from middle age up to around 80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are often associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have been suggested as biomarkers of immune system aging. Thus, the manner in which CMV and the host immune system interact is critical in determining the "age" of specific immunity. We may therefore consider immunosenescence in some respects as an infectious state. This implies that interventions aimed at the pathogen may improve the organ system affected. Hence, CMV-directed anti-virals or vaccination may have beneficial effects on immunity in later life.