Seroprevalence of hepatitis C, hepatitis B virus and syphilis in HIV-1 infected patients in Shandong, China
Seroprevalence of hepatitis C, hepatitis B virus and syphilis in HIV-1 infected patients in Shandong, China
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DOI：
10.1258/ijsa.2012.011411
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发表时间：
2012-09-01
影响因子：
1.4
通讯作者：
Fu, J. H.
中科院分区：
文献类型：
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作者：
Zhao, Y. S.;Su, S. L.;Fu, J. H.
为了确定中国山东省HIV-1感染者中丙型肝炎病毒（HCV）、B肝炎病毒（HBV）和梅毒的血清阳性率及其相关危险因素，我们在知情同意后对2000年至2010年期间所有符合条件的参与者进行了抗HCV抗体、B肝炎表面抗原（HBsAg）和梅毒非密螺旋体抗体的检测。在2087例HIV感染者中，抗-HCV抗体阳性率为41.2%，HBsAg阳性率为12.6%，RPR阳性率为19.6%。在多因素Logistic回归模型中，男性（调整后的比值比[aOR] = 1.41）、少数民族（aOR = 1.72）、梅毒感染（aOR = 1.40）、既往有偿献血者（aOR = 3.36）、输血者（aOR = 2.91）和注射吸毒者（aOR = 1.98）与HCV感染显著相关。HCV感染（aOR = 1.40）和男男性行为（aOR = 2.38）与梅毒感染显著相关。在所有描述的HIV感染亚组中，经常观察到HCV、HBV和梅毒的合并感染。本研究结果提示，有必要对所有中国HIV感染者进行梅毒和病毒的筛查。
To determine the seroprevalence of hepatitis C virus (HCV), hepatitis B virus (HBV) and syphilis in HIV-1-infected patients and related risk factors in Shandong province, China, we tested all eligible participants between 2000 and 2010 for the presence of anti-HCV antibody, hepatitis B surface antigen (HBsAg) and non-treponemal antibodies for syphilis after informed consent. Among 2087 HIV-infected patients, anti-HCV antibody was present in 41.2%, HBsAg in 12.6% and rapid plasma reagin (RPR) reactivity in 19.6%. In the multivariate logistic regression model, male gender (adjusted odds ratio [aOR] = 1.41), minority ethnicity (aOR = 1.72), syphilis infection (aOR = 1.40), former paid blood donors (aOR = 3.36), blood transfusion recipients (aOR = 2.91) and injection drug users (aOR = 1.98) were significantly associated with HCV infection. HCV infection (aOR = 1.40) and being men who have sex with men (aOR = 2.38) were significantly associated with syphilis infection. Co-infection with HCV, HBV and syphilis was observed frequently in all described subgroups of HIV infection. The results of this study suggest that it is necessary to screen for these viruses and syphilis in all Chinese HIV-infected patients.