MicroRNA-29b-3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
MicroRNA-29b-3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
复制标题
MicroRNA-29b-3p通过IL32/AKT信号通路抑制口腔鳞癌细胞迁移和侵袭
DOI：
10.1111/jcmm.14794
复制
发表时间：
2019-11-03
影响因子：
5.3
通讯作者：
Li, Xiaojie
中科院分区：
文献类型：
--
作者：
He, Jianya;Ye, Wen;Li, Xiaojie
口腔鳞状细胞癌（Oral squamous cell carcinoma，OSCC）是一种侵袭性强、预后差的恶性肿瘤。我们先前通过微流控技术分离了与侵袭性肿瘤前沿相似的最具侵袭性的细胞，并在我们先前的工作中探索了它们差异表达的microRNA（miRNAs）。在这里，我们验证了miR-29 b-3 p作为抑制OSCC细胞迁移和侵袭的守卫者，并且在最具侵袭性的细胞中下调。此外，miR-29 b-3 p的侵袭抑制作用是通过IL-32/AKT途径实现的。因此，miR-29 b-3 p和IL 32可能作为阻断OSCC进展和改善其预后的治疗靶点。
Oral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the miR‐29b‐3p as a guarder that suppressed migration and invasion of OSCC cells and was down‐regulated in the most invasive cells. Besides that, the invasion suppression role of miR‐29b‐3p was achieved through the IL32/AKT pathway. Thus, miR‐29b‐3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC.