Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS
Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS
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DOI：
10.1097/00002030-200205030-00011
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发表时间：
2002-05-03
期刊：
影响因子：
3.8
通讯作者：
Rimland, D
中科院分区：
文献类型：
--
作者：
Franco-Paredes, C;Bellehemeur, T;Rimland, D
水痘-带状疱疹病毒（VZV）是HIV感染者第二常见的眼部病原体。VZV视网膜炎估计发生在0.6%的HIV感染患者中，并且可能发生在两种临床综合征之一中。第一种是急性视网膜坏死综合征，也可以在免疫活性宿主中看到。第二种临床综合征发生在CD 4细胞计数通常< 50 × 10（6）/l的患者中，称为进行性外视网膜坏死。据报道，在HIV感染患者中，VZV视网膜炎与其他VZV中枢神经系统表现（如脑炎和肌病）同时发生。此外，VZV球后视神经炎预示着VZV视网膜炎最近已被描述在艾滋病毒感染的患者谁遭受了最近发作的带状疱疹。在此，我们报告的情况下，艾滋病毒感染的个人谁提出了VZV脑膜炎和球后视神经炎，发病前进行性外视网膜坏死。我们还回顾了文献报道的7个额外的情况下，球后视神经炎发病前的VZV视网膜炎。(C)2002年利平科特威廉姆斯威尔金斯。
Varicella-Zoster Virus (VZV) is the second most common ocular pathogen in patients with HIV infection. VZV retinitis is estimated to occur in 0.6% of patients with HIV infection and may occur in one of two clinical syndromes. The first is the acute retinal necrosis syndrome, which also may be seen in immunocompetent hosts. The second clinical syndrome occurs in patients with CD4 cell counts typically < 50 x 10(6)/l and is termed progressive outer retinal necrosis. VZV retinitis has been reported to occur simultaneously with other VZV central nervous system manifestations such as encephalitis and myelitis in HIV-infected patients. In addition, VZV retrobulbar optic neuritis heralding VZV retinitis has recently been described in HIV-infected patients who had suffered a recent episode of dermatomal herpes zoster. Herein we report the case of an HIV-infected individual who presented with VZV meningitis and retrobulbar optic neuritis that preceded the onset of progressive outer retinal necrosis. We also review of the literature of seven additional reported cases of retrobulbar optic neuritis preceding the onset of VZV retinitis. (C) 2002 Lippincott Williams Wilkins.