Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA.
Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA.
复制标题
DOI：
10.3390/pharmaceutics4010130
复制
发表时间：
2012-02-01
期刊：
影响因子：
5.4
通讯作者：
Higashi T
中科院分区：
文献类型：
--
作者：
Arima H;Motoyama K;Higashi T
基因、短发夹状RNA(ShRNA)和小干扰RNA(SiRNA)可以通过遗传物质进入哺乳动物细胞表达新的蛋白质或抑制蛋白质的表达而特别用于疾病的治疗。聚酰胺胺(PAMAM)StarburstTM树状大分子被用作基因、shRNA和siRNA的非病毒载体(载体)。近年来，多功能PAMAM树枝状大分子可广泛应用于生物医学领域，包括基因和核酸药物的细胞内递送。在此背景下，本文综述了PAMAM树状大分子与环糊精(CyDS)在基因、shRNA和siRNA传递方面的最新研究成果。
Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) StarburstTM dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recently, multifunctional PAMAM dendrimers can be used for the wide range of biomedical applications including intracellular delivery of genes and nucleic acid drugs. In this context, this review paper provides the recent findings on PAMAM dendrimer conjugates with cyclodextrins (CyDs) for gene, shRNA and siRNA delivery.