Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing
Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing
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DOI：
10.1152/japplphysiol.00386.2022
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发表时间：
2022-12-01
影响因子：
3.3
通讯作者：
Pham, Luu V.
中科院分区：
文献类型：
--
作者：
Kim, Lenise J.;Alexandre, Chloe;Pham, Luu V.
肥胖与睡眠呼吸障碍（SDB）和睡眠不足有关。肥胖患者在 SDB 治疗后，残留的日间嗜睡和睡眠障碍通常持续存在，这表明肥胖对呼吸和睡眠有独立影响。然而，检查肥胖患者睡眠结构与 SDB 之间的关系很复杂，并且可能受到多种因素的影响。本研究的主要目的是探讨肥胖相关的睡眠结构变化与 SDB 之间的关系。对 15 只瘦 C57BL/6J 小鼠和 17 只具有相同遗传背景的饮食诱导肥胖 (DIO) 小鼠进行睡眠记录。对睡眠唤醒和呼吸暂停进行手动评分。呼吸唤醒被分类为与每分钟通气量 (V-E) 较基线下降≥ 30% 相关的事件。我们应用睡眠期间 V-E 的庞加莱分析来估计呼吸变异性。肥胖使觉醒频率增加 45%，且这种增加与呼吸暂停无关。两组小鼠的呼吸唤醒仅占唤醒的 15%。 DIO 小鼠在非快速眼动 (NREM) 睡眠期间的呼吸变异性显着较高，但与觉醒频率无关。我们的结果表明，肥胖会导致睡眠碎片化，与 SDB 严重程度无关。新的和值得注意的我们的饮食诱发肥胖 (DIO) 模型再现了人类肥胖的睡眠特征，包括睡眠碎片化、呼吸暂停频率增加和呼吸变异性更大。 DIO 会导致睡眠碎片化，与呼吸暂停的严重程度无关。 DIO 小鼠的睡眠碎片化主要归因于非呼吸唤醒。睡眠期间呼吸变异性的增加并不能解释 DIO 中较高的唤醒频率。我们的研究结果为检查肥胖患者的睡眠提供了理论基础，即使他们的睡眠呼吸障碍得到了充分的治疗。
Obesity is associated with sleep-disordered breathing (SDB) and unrefreshing sleep. Residual daytime sleepiness and sleep impairments often persist after SDB treatment in patients with obesity, which suggests an independent effect of obesity on breathing and sleep. However, examining the relationship between sleep architecture and SDB in patients with obesity is complex and can be confounded by multiple factors. The main goal of this study was to examine the relationship between obesity-related changes in sleep architecture and SDB. Sleep recordings were performed in 15 lean C57BL/6J and 17 diet-induced obesity (DIO) mice of the same genetic background. Arousals from sleep and apneas were manually scored. Respiratory arousals were classified as events associated with >= 30% drops in minute ventilation (V-E) from baseline. We applied Poincare analysis of V-E during sleep to estimate breathing variability. Obesity augmented the frequency of arousals by 45% and this increase was independent of apneas. Respiratory arousals comprised only 15% of the arousals in both groups of mice. Breathing variability during non-rapid-eye-movment (NREM) sleep was significantly higher in DIO mice, but it was not associated with arousal frequency. Our results suggest that obesity induces sleep fragmentation independently of SDB severity.NEW & NOTEWORTHY Our diet-induced obesity (DIO) model reproduces sleep features of human obesity, including sleep fragmentation, increased apnea frequency, and larger breathing variability. DIO induces sleep fragmentation independently of apnea severity. Sleep fragmentation in DIO mice is mainly attributed to non-respiratory arousals. Increased breathing variability during sleep did not account for the higher arousal frequency in DIO. Our results provide a rationale to examine sleep in patients with obesity even when they are adequately treated for sleep-disordered breathing.