The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5α-reduced metabolites
The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5α-reduced metabolites
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DOI：
10.1016/s0091-3057(02)00968-1
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发表时间：
2002-12-01
影响因子：
3.6
通讯作者：
Svare, B
中科院分区：
文献类型：
--
作者：
Frye, CA;Rhodes, ME;Svare, B
睾酮（T）的正性快感效应可能是由其代谢产物双氢睾酮（DHT）或3 α-雄甾烷酮（3 α-二醇）在丘脑核（NA）中的作用介导的。在实验1中，在不同的时间点，向成年、完整的雄性大鼠全身给予1 mg T、DHT、3 α-二醇或溶媒，以检查NA中雄激素的浓度。给予3 α-二醇的大鼠在包括NA的大脑区域中具有显著增加的3 α-二醇浓度。这些数据与我们实验室先前的数据一致，表明当全身给药时，3 α-二醇比T或DHT更有效地激发条件性位置偏爱（CPP）。在实验2中，大鼠接受植入物的T，DHT或3 α-二醇的NA之前，立即放置在CPP装置的调节天。植入T、DHT或3 α-二醇，但不植入溶剂，显著增加了试验当天在灭菌室非首选侧花费的时间。这种作用仅由NA的外壳而不是NA的核心的雄激素刺激产生。因此，我们以前发现的增强CPP的雄激素方案在NA区域产生了3 α-二醇浓度的最大增加，并且将T、DHT或3 α-二醇直接植入NA增强CPP的壳而不是核。这些数据与T的享乐效应可能是由于其代谢产物在NA中的作用的假设一致。(C)2002年爱思唯尔科技有限公司All rights reserved.
Testosterone (T)'s positive hedonic effects may be mediated by actions of its metabolites, dihydrotestosterone (DHT) or 3alpha-androstanediol (3alpha-diol), in the nucleus accumbens (NA). In Experiment 1, adult, intact, male rats were systemically administered 1 mg of T, DHT, 3alpha-diol or vehicle, at different time points to examine concentrations of androgens in the NA. Rats administered 3alpha-diol had significantly increased concentrations of 3alpha-diol in the region of the brain encompassing the NA. These data are consistent with previous data from our laboratory demonstrating that 3alpha-diol elicits a conditioned place preference (CPP) more effectively than either T or DHT, when administered systemically. In Experiment 2, rats received implants of T, DHT or 3alpha-diol to the NA immediately prior to placement in the CPP apparatus on conditioning days. Implants of T, DHT or 3alpha-diol, but not vehicle, significantly increased time spent on the non-preferred side of the chamber on the test day. This effect was only produced by androgenic stimulation of the shell of the NA and not the core of the NA. Thus, androgen regimens we have previously found to enhance CPP produced the greatest increases in 3alpha-diol concentrations in the NA region and direct implants of T, DHT or 3alpha-diol to the shell, but not the core, of the NA enhanced CPP. These data are consistent with the hypothesis that the hedonic effects of T may be due to actions of its metabolites in the NA. (C) 2002 Elsevier Science Inc. All rights reserved.