Muscle chemoreflex alters vascular conductance in nonischemic exercising skeletal muscle.
Muscle chemoreflex alters vascular conductance in nonischemic exercising skeletal muscle.
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肌肉化学反射改变非缺血运动骨骼肌中的血管电导。
DOI：
10.1152/jappl.1994.77.6.2761
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Clifford,PS
中科院分区：
文献类型：
--
作者：
Mittelstadt,SW;Bell,LB;O'Hagan,KP;Clifford,PS
先前的研究表明，肌肉化学反射引起对运动的血压反应增强，并部分恢复缺血肌肉的血流。本研究旨在探讨肌肉化学反射对非缺血运动骨骼肌血流量的影响。在每个实验中，狗跑在10公里/小时8-16分钟，肌肉化学反射诱发减少后肢血流量在4分钟的时间间隔（0-80%）。动脉血压，后肢血流量，前肢血流量和前肢血管传导性的平均值在最后一分钟在每个闭塞水平。刺激肌肉化学反射引起动脉血压和前肢血流量增加，前肢血管传导性降低。前肢血管传导性的降低表明，肌肉化学反射引起非缺血运动前肢血管收缩。尽管血管传导性降低，但由升压反应引起的驱动压力增加足以产生增加的前肢血流量。
Previous studies have shown that the muscle chemoreflex causes an augmented blood pressure response to exercise and partially restores blood flow to ischemic muscle. The purpose of this study was to investigate the effects of the muscle chemoreflex on blood flow to nonischemic exercising skeletal muscle. During each experiment, dogs ran at 10 kph for 8–16 min and the muscle chemoreflex was evoked by reducing hindlimb blood flow at 4-min intervals (0–80%). Arterial blood pressure, hindlimb blood flow, forelimb blood flow, and forelimb vascular conductance were averaged over the last minute at each level of occlusion. Stimulation of the muscle chemoreflex caused increases in arterial blood pressure and forelimb blood flow and decreases in forelimb vascular conductance. The decrease in forelimb vascular conductance demonstrates that the muscle chemoreflex causes vasoconstriction in the nonischemic exercising forelimb. Despite the decrease in vascular conductance, the increased driving pressure caused by the pressor response was large enough to produce an increased forelimb blood flow.