Sub-nanoliter nuclear magnetic resonance coils fabricated with multilayer soft lithography
Sub-nanoliter nuclear magnetic resonance coils fabricated with multilayer soft lithography
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DOI：
10.1088/0960-1317/19/9/095001
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发表时间：
2009-09
影响因子：
2.3
通讯作者：
Matthew H. C. Lam;Mark A Homenuke;C. Michal;C. Hansen
中科院分区：
文献类型：
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作者：
Matthew H. C. Lam;Mark A Homenuke;C. Michal;C. Hansen
我们描述了亚纳升体积的核磁共振（NMR）收发器线圈，很容易服从基于PDMS的微流体集成的制造和表征。核磁共振线圈的构造液态金属注入到螺线管腔周围的微通道使用连续的复制品成型和PDMS层的粘合创建。这种构造技术允许在高度集成的微流体系统内集成具有螺线管、环形或其他三维几何形状的NMR线圈，并且是朝向基于NMR的芯片上化学筛选和分析的一步。由于构造材料的导电性和磁性，目前的原理验证实现显示出有限的灵敏度和分辨率。然而，NMR测量和有限元模拟与当前设备的几何形状表明，这些材料的优化将允许从小于1 nL的溶液中的亚毫摩尔浓度的样品的光谱的收集。
We describe the fabrication and characterization of sub-nanoliter volume nuclear magnetic resonance (NMR) transceiver coils that are easily amenable to integration within PDMS-based microfluidics. NMR coils were constructed by the injection of liquid metal into solenoidal cavities created around a microchannel using consecutive replica molding and bonding of PDMS layers. This construction technique permits the integration of NMR coils with solenoidal, toroidal or other three-dimensional geometries within highly integrated microfluidic systems and are one step toward NMR-based chemical screening and analysis on chip. The current proof-of-principle implementation displays limited sensitivity and resolution due to the conductivity and magnetic susceptibilities of the construction materials. However, NMR measurements and finite-element simulations made with the current device geometry indicate that optimization of these materials will allow for the collection of spectra from sub-millimolar concentration samples in less than 1 nL of solution.