Antibiotic resistance, stewardship, and consumption - Authors' reply.
Antibiotic resistance, stewardship, and consumption - Authors' reply.
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抗生素耐药性、管理和消费——作者的回复。
DOI：
10.1016/s2542-5196(18)30263-8
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Collignon P
中科院分区：
文献类型：
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作者：
Collignon P
我们同意Koen B Pouwels及其同事的观点，即关联并不意味着因果关系。在我们的论文中，我们承认使用国家级抗生素使用和耐药模式数据的局限性，并且抗生素使用是抗生素耐药性的重要因素。我们注意到，我们的研究结果表明，人类学因素导致的耐药细菌的传播至少与抗生素的使用一样重要，这一结果得到了其他研究的支持。1抗生素销售数据（IQVIA MIDAS数据库）具有局限性，但这些数据提供了关于抗生素消费的全球统一信息的唯一来源。其他人已经验证了IQVIA MIDAS，并证明与欧洲抗菌药物消费监测网络的数据具有很强的相关性。2我们使用了世卫组织114个成员国的全球耐药性数据。我们还使用了来自ResistanceMap的数据，并询问了有关大肠杆菌耐药性的文献检索。我们观察到的结果在数据集之间相似。
We agree with Koen B Pouwels and colleagues, that association does not mean cause and effect. In our paper, we acknowledged limitations in using national-level data on antibiotic usage and resistance patterns, and that antibiotic use is an important factor in antibiotic resistance. We note that our results, which show that the spread of resistant bacteria by anthropological factors is at least as important as antibiotic use, are supported by other studies. 1Antibiotic sales data (IQVIA MIDAS database) have limitations, but these data provide the only source of harmonised global information on antibiotic consumption. Others have validated IQVIA MIDAS and demonstrated strong correlation with data from the European Surveillance of Antimicrobial Consumption Network. 2 We used global resistance data on 114 member states from WHO. We also used data from ResistanceMap and interrogated literature searches on Escherichia coli resistance. The results we observed were similar across the datasets.