The role of MAPK in CD4+ T cells toll-like receptor 9-mediated signaling following HHV-6 infection
The role of MAPK in CD4+ T cells toll-like receptor 9-mediated signaling following HHV-6 infection
复制标题
DOI：
10.1016/j.virol.2011.09.026
复制
发表时间：
2012-01-05
期刊：
影响因子：
3.7
通讯作者：
Yao, Kun
中科院分区：
文献类型：
--
作者：
Chi, Jing;Wang, Fang;Yao, Kun
人疱疹病毒-6（HHV-6）是一种重要的免疫抑制和免疫调节病毒，主要感染免疫细胞（主要是CD 4（+）T细胞）并强烈抑制感染细胞的增殖。Toll样受体是一种模式识别受体，对于开发适当的先天免疫防御感染至关重要。为了了解CD 4（+）T细胞在HHV-6感染的先天性应答中的作用以及TLR的参与，我们使用体外感染模型，观察到CD 4（+）T细胞的感染通过上调Toll样受体9（TLR 9）导致JNK/SAPK的激活。Annexin V-PI染色结果显示HHV-6A具有较强的细胞凋亡诱导作用，并伴有JNK的激活。HHV-6A感染也诱导凋亡反应相关的细胞因子IL-6和TNF-α。(C)2011 Elsevier Inc. All rights reserved.
Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4(+) T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4(+) T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4(+) T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-alpha also induced by HHV-6A infection. (C) 2011 Elsevier Inc. All rights reserved.