Physical activity is correlated with serum leptin independent of obesity results of the national surveillance of risk factors of noncommunicable diseases in Iran (SuRFNCD-2007)
Physical activity is correlated with serum leptin independent of obesity results of the national surveillance of risk factors of noncommunicable diseases in Iran (SuRFNCD-2007)
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DOI：
10.1016/j.metabol.2010.04.016
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发表时间：
2010-12-01
影响因子：
9.8
通讯作者：
Nakhjavani, Manouchehr
中科院分区：
文献类型：
--
作者：
Esteghamati, Alireza;Khalilzadeh, Omid;Nakhjavani, Manouchehr
关于瘦素与体力活动（PA）在人群水平上的关系的报道很少。本研究探讨了血清瘦素浓度和PA之间的关系，在一个全国代表性的样本3001伊朗成年人年龄在25至64岁。对第三次全国非传染性疾病危险因素监测资料进行分析。使用全球体力活动问卷，PA的持续时间和强度进行了评估，在3个领域：工作，通勤和娱乐。使用PA强度的代谢当量计算总PA。血清瘦素测定采用酶联免疫吸附法。校正年龄、居住地区、吸烟、体重指数和腰围后，总PA（男性r=-0.129，P = 0.038，女性r=-0.226，P = 0.006），高强度活动的持续时间（男性r=-0.120，P =.044，女性r=-0.154，P =.019），中等强度活动的持续时间（男性r=-0.114，P = 0.047;女性r=-0.160，P = 0.018）和久坐时间（男性r=0.194，P= 0.014;女性r=-0.204，P = 0.007）与血清瘦素显著相关。在两种性别中，PA类别较高的参与者血清瘦素水平显着降低。总之，我们的研究结果表明，瘦素浓度和PA之间的负相关独立的年龄，性别，吸烟，和身体肥胖。我们的研究结果表明PA对血清瘦素的调节作用。(C)2010年爱思唯尔公司All rights reserved.
Reports on the relationship between leptin and physical activity (PA) at the population level are scarce. The present study examined the relationship between serum leptin concentrations and PA in a nationally representative sample of 3001 Iranian adults aged 25 to 64 years. Data of our third national surveillance of risk factors of noncommunicable diseases were analyzed. Using the Global Physical Activity Questionnaire, the duration and intensity of PA were evaluated in 3 domains: work, commuting, and recreation. Total PA was calculated using metabolic equivalents for PA intensity. Serum leptin was measured with an enzyme-linked immunosorbent assay. After adjustment for age, area of residence, smoking, body mass index, and waist circumference, total PA (r=-0.129, P=.038 in men and r=-0.226, P=.006 in women), the duration of vigorous-intensity activity (r=-0.120, P=.044 in men and r=-0.154, P=.019 in women), the duration of moderate-intensity activity (r=-0.114, P=.047 in men and r=-0.160, P=.018 in women), and time spent on sedentary behaviors (r=0.194, P=.014 in men and r=-0.204, P=.007 in women) were significantly correlated with serum leptin. In both sexes, participants in higher categories of PA had significantly lower serum leptin levels. In conclusion, our results demonstrated an inverse association between leptin concentrations and PA independent of age, sex, smoking, and body adiposity. Our results point to the regulatory effects of PA on serum leptin. (C) 2010 Elsevier Inc. All rights reserved.