Oestrogenic Regulation of Mitochondrial Dynamics.
Oestrogenic Regulation of Mitochondrial Dynamics.
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DOI：
10.3390/ijms23031118
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发表时间：
2022-01-20
影响因子：
5.6
通讯作者：
Kararigas G
中科院分区：
文献类型：
--
作者：
Beikoghli Kalkhoran S;Kararigas G
生物性别影响疾病的发展和进展。类固醇激素17β-雌二醇（E2），沿着其受体，预计在性别差异的表现中发挥主要作用。E2以系统特异性方式发挥多效性作用。线粒体是E2的中心靶点之一，并且已知它们的生物发生和呼吸受E2调节。最近，E2还调节线粒体融合-裂变动力学，从而影响细胞代谢变得很明显。本文的目的是讨论E2协调健康和疾病中心血管和神经系统线粒体动力学几个组成部分的活性的调节途径。我们的结论是，E2调节线粒体动力学，以维持线粒体网络，促进线粒体融合和衰减线粒体分裂在心血管和神经系统。
Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion–fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems.
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影响因子：
4.8
作者：
Bevan RJ;Williams PA;Waters CT;Thirgood R;Mui A;Seto S;Good M;Morgan JE;Votruba M;Erchova I
通讯作者：
Erchova I
影响因子：
3.7
作者：
Bouche L;Kamel R;Tamareille S;Garcia G;Villedieu C;Pillot B;Gueguen N;Chehaitly A;Chao de la Barca JM;Beaumont J;Baetz D;Ovize M;Sesaki H;Henrion D;Reynier P;Lenaers G;Prunier F;Mirebeau-Prunier D
通讯作者：
Mirebeau-Prunier D
影响因子：
64.5
作者：
Chen H;Vermulst M;Wang YE;Chomyn A;Prolla TA;McCaffery JM;Chan DC
通讯作者：
Chan DC
影响因子：
5.6
作者：
Altinbas, Lukas;Bormann, Nicole;Kararigas, Georgios
通讯作者：
Kararigas, Georgios
DOI：
10.1161/hypertensionaha.112.195511
发表时间：
2012-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Carnevale D;Mascio G;D'Andrea I;Fardella V;Bell RD;Branchi I;Pallante F;Zlokovic B;Yan SS;Lembo G
通讯作者：
Lembo G