A Crossover Study Comparing the Effect of Particle Size on the Distribution of Radiocolloid in Patients
A Crossover Study Comparing the Effect of Particle Size on the Distribution of Radiocolloid in Patients
复制标题
比较粒径对放射性胶体在患者体内分布影响的交叉研究
DOI：
10.1097/00003072-198105000-00005
复制
发表时间：
1981
影响因子：
10.6
通讯作者：
L. Rosenthall
中科院分区：
文献类型：
--
作者：
R. Kloiber;B. Damtew;L. Rosenthall
在 15 名患者中，每人对两种颗粒大小相差 5 至 20 倍的放射性胶体制剂进行了比较。较小的胶体（测量值小于 80 nm）显示肝脏和脾脏的计算目标与背景比率相对下降，而骨髓则相对增加。通过骨髓与软组织背景比率测量，较小颗粒在骨髓中的吸收增加比较大胶体颗粒高约 50%。对于给定的给药剂量，使用较小的颗粒尺寸可以在一半到三分之一的时间内获得类似的骨髓图像。
Two radiocolloid preparations, differing in particle size by a factor of 5 to 20, were compared in each of 15 patients. The smaller colloid, measuring less than 80 nm, showed a relative decrease in the calculated target to background ratios for the liver and spleen and an increase for the bone marrow. The increased uptake of the smaller particle in the bone marrow, as measured by the bone marrow to soft-tissue background ratio, was about 50% higher than that of the larger colloidal particles. Comparable marrow images can be obtained in a half to a third of the time with the smaller particle size for a given administered dose.