In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with 3He Lung Morphometry
In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with 3He Lung Morphometry
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DOI：
10.1148/radiol.11102226
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发表时间：
2011-09-01
期刊：
影响因子：
19.7
通讯作者：
Yablonskiy, Dmitriy A.
中科院分区：
文献类型：
--
作者：
Quirk, James D.;Lutey, Barbara A.;Yablonskiy, Dmitriy A.
目的：为了定量表征早期肺气肿的变化，在当前和以前的吸烟者与非侵入性氦3（He-3）肺形态测量的肺显微结构，并比较这些结果与临床标准，肺功能测试（PFT）和低剂量计算机断层扫描（CT）。材料和方法：这项研究是由当地机构审查委员会批准，所有受试者提供了知情同意书。30名当前和以前的吸烟者，每个人都有至少30包年的吸烟史，在PFT时有轻度或无异常，进行了He-3肺形态测定。该技术基于超极化3 He气体的扩散MR成像，并产生腺泡气道几何参数的定量局部体内测量，如气道半径、肺泡深度和每单位肺体积的肺泡数。这些测量使计算标准的形态特征，如平均线性截距和表面-体积ratio.Results：非侵入性的他-3肺形态测定法被用来检测腺泡结构的改变，吸烟者与正常的PFT结果。与第一秒用力呼气量（FEV 1）与用力肺活量（FVC）比值最大的吸烟者相比，慢性阻塞性肺疾病患者的肺泡深度显著降低（0.07 mm vs 0.13 mm），腺泡管显著增大（0.36 mm vs 0.3 mm）。最健康受试者的平均肺泡几何形状测量结果与使用侵入性技术获得的文献值（腺泡管半径，0.3 mm;肺泡深度，在功能残气量以上1 L时为0.14 mm）具有极好的定量一致性。He-3肺形态测量显示比PFT和CT更大的异常。没有不良事件与吸入He-3气体。结论：He-3肺形态测量产生有价值的非侵入性洞察早期肺气肿的变化，肺泡几何结构与传统技术相比，灵敏度增加。(C)RSNA，2011年
Purpose: To quantitatively characterize early emphysematous changes in the lung microstructure of current and former smokers with noninvasive helium 3 (He-3) lung morphometry and to compare these results with the clinical standards, pulmonary function testing (PFT) and low-dose computed tomography (CT).Materials and Methods: This study was approved by the local institutional review board, and all subjects provided informed consent. Thirty current and former smokers, each with a minimum 30-pack-year smoking history and mild or no abnormalities at PFT, underwent He-3 lung morphometry. This technique is based on diffusion MR imaging with hyperpolarized 3 He gas and yields quantitative localized in vivo measurements of acinar airway geometric parameters, such as airway radii, alveolar depth, and number of alveoli per unit lung volume. These measurements enable calculation of standard morphometric characteristics, such as mean linear intercept and surface-to-volume ratio.Results: Noninvasive He-3 lung morphometry was used to detect alterations in acinar structure in smokers with normal PFT findings. When compared with smokers with the largest forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) ratio, those with chronic obstructive pulmonary disease had significantly reduced alveolar depth (0.07 mm vs 0.13 mm) and enlarged acinar ducts (0.36 mm vs 0.3 mm). The mean alveolar geometry measurements in the healthiest subjects were in excellent quantitative agreement with literature values obtained by using invasive techniques (acinar duct radius, 0.3 mm; alveolar depth, 0.14 mm at 1 L above functional residual capacity). He-3 lung morphometry depicted greater abnormalities than did PFT and CT. No adverse events were associated with inhalation of He-3 gas.Conclusion: He-3 lung morphometry yields valuable noninvasive insight into early emphysematous changes in alveolar geometry with increased sensitivity compared with conventional techniques. (C) RSNA, 2011