An alphabeta T-cell-independent immunoprotective response towards gut coccidia is supported by gammadelta cells.
An alphabeta T-cell-independent immunoprotective response towards gut coccidia is supported by gammadelta cells.
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针对肠道球虫的非 Alphata T 细胞独立的免疫保护反应得到了 γδ 细胞的支持。
DOI：
10.1046/j.1365-2567.2000.00122.x
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发表时间：
2000
期刊：
影响因子：
6.4
通讯作者：
Hayday,AC
中科院分区：
文献类型：
--
作者：
Smith,AL;Hayday,AC
虽然γδ细胞通常被假设为提供“第一道防线”，但γδ细胞缺陷小鼠通常对病原体的易感性仅略高。由于γδ细胞在上皮细胞中富集，因此重要的是要确定γδ细胞区室是否缺乏对嗜上皮性病原体的免疫保护能力，或者这种活性是否存在，但与αβ T细胞的活性相比是多余的。在这项工作中，在用球虫寄生虫蠕虫状艾美耳球虫感染αβ T细胞缺陷小鼠的肠上皮后，γδ细胞被证明支持其他淋巴细胞的快速活化，并赋予可通过中和干扰素γ而根除的可转移的抗病原体作用。然而，与αβ T细胞不同，γδ细胞的这些作用没有显示出功能性免疫记忆的证据。这些结果与球虫病（一种经济上重要的牲畜疾病）直接相关，并且应该与涉及αβ T细胞缺陷的感染（例如获得性免疫缺陷综合征（AIDS）患者的隐孢子虫病）具有普遍相关性。
Although γδ cells are commonly hypothesized to provide a ‘first line of defence’, γδ‐cell‐deficient mice are generally only marginally more susceptible to pathogens. Because γδ cells are enriched within epithelia, it is important to resolve whether immunoprotective capacity towards epithelial‐tropic pathogens is absent from the γδ‐cell compartment, or whether such activity is present but simply redundant with that of αβ T cells. In this work, following infection of the intestinal epithelium of αβ T‐cell‐deficient mice with the coccidian parasite,Eimeria vermiformis, γδ cells were shown to support the rapid activation of other lymphoid cells and to confer a transferable antipathogen effect that could be eradicated by neutralization of interferon‐γ. However, unlike αβ T cells, these effects of γδ cells showed no evidence of functional immunological memory. These results are directly relevant to coccidiosis, an economically significant disease of livestock, and should have general relevance to infections involving αβ T‐cell deficiencies, e.g. cryptosporidiosis in patients with acquired immune deficiency syndrome (AIDS).