Fundamental mechanisms underlying altered behavior following chronic administration of psychomotor stimulants.
Fundamental mechanisms underlying altered behavior following chronic administration of psychomotor stimulants.
复制标题
长期服用精神运动兴奋剂后行为改变的基本机制。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Kilbey Mm
中科院分区：
文献类型：
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作者：
Ellinwood Eh;Kilbey Mm
：过去十年，精神运动兴奋剂引起的人类和实验动物的异常行为为研究精神病的生物行为基础提供了模型。长期服用精神运动兴奋剂而发生的行为改变似乎可归因于五种主要现象：其中之一是条件反射，涉及一种整体重组，其生物学基础知之甚少。反映点燃机制的改变代表膜机制的变化，导致电信号的传播增强。第三种机制涉及药物代谢系统的适应，最后两种机制涉及胺能神经元功能，即多巴胺水平降低，其他胺系统可能发生变化，以及多巴胺受体数量增加。提出了将长期服用精神运动兴奋剂导致的行为重组与这些现象联系起来的证据。
: Psychomotor stimulant-induced abnormal behavior in man and experimental animals has provided a model for investigation of the biobehavioral basis of psychosis for the past decade. The altered behavior which occurs with chronic administration of psychomotor stimulants appears to be attributable to five major phenomena: One of these, conditioning, involves a global reorganization whose biological bases are little understood. Alterations reflecting kindling mechanisms represent changes in membrane mechanisms resulting in enhanced propagation of electrical signals. A third mechanism involves adaptation of drug metabolism systems, and the final two involve aminergic neuronal function, i.e., decreased levels of dopamine and possibly alterations in other amine systems and increased number of dopamine receptors. Evidence linking behavioral reorganization as a result of chronic administraton of psychomotor stimulants with these phenomena is presented.