Use of over-the-counter medications during pregnancy
Use of over-the-counter medications during pregnancy
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DOI：
10.1016/j.ajog.2005.02.100
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发表时间：
2005-09-01
影响因子：
9.8
通讯作者：
Honein, MA
中科院分区：
文献类型：
--
作者：
Werler, MM;Mitchell, AA;Honein, MA
目的：妊娠期最常用的药物是非处方药或非处方药，尽管对其风险或安全性的研究很少。我们描述了孕妇使用非处方药的模式。研究设计：在 2 项出生缺陷病例对照研究中收集数据：斯隆流行病学中心出生缺陷研究 (BDS) 和国家出生缺陷预防研究 (NBDPS)。结果：在斯隆流行病学中心出生缺陷研究中，有 7563 名畸形和非畸形后代的母亲和 在国家出生缺陷预防研究中，2970 名非畸形后代的母亲中，使用对乙酰氨基酚、布洛芬和伪麻黄碱的比例分别至少为 65%、18% 和 15%。在参与斯隆流行病学中心出生缺陷研究的妇女中，从 1976 年到 2004 年，怀孕期间阿司匹林和扑尔敏的使用量有所减少，而布洛芬、伪麻黄碱、苯海拉明、右美沙芬和愈创甘油醚的使用量则有所增加。在参与国家出生缺陷预防研究的女性中，对乙酰氨基酚、伪麻黄碱、苯海拉明和愈创甘油醚的使用在怀孕期间高于怀孕前。结论：研究结果表明，大多数孕妇使用非处方药。有必要进行研究来检查与特定出生缺陷相关的特定非处方药，以便更好地告知孕妇风险和安全性。 (c) 2005 Mosby, Inc. 保留所有权利。
Objective: The most common medications used in pregnancy are nonprescription or over-the-counter medications, although there has been little research on their risks or safety. We describe the patterns of over-the-counter medication use among pregnant women.Study design: Data were collected in 2 case-control studies of birth defects: the Slone Epidemiology Center Birth Defects Study (BDS) and the National Birth Defects Prevention Study (NBDPS).Results: Among 7563 mothers of malformed and nonmalformed offspring in the Slone Epidemiology Center Birth Defects Study and 2970 mothers of nonmalformed offspring in the National Birth Defects Prevention Study, acetaminophen, ibuprofen, and pseudoephedrine were used by at least 65%, 18%, and 15%, respectively. Among women in the Slone Epidemiology Center Birth Defects Study, the use in pregnancy of aspirin and chlorpheniramine decreased from 1976 to 2004 and of ibuprofen, pseudoephedrine, diphenhydramine, dextromethorphan, and guaifenesin increased. Among women in the National Birth Defects Prevention Study, the use of acetaminophen, pseudoephedrine, diphenhydramine, and guaifenesin was higher during pregnancy than before pregnancy.Conclusion: Findings show that over-the-counter medications are used by most pregnant women. Studies that examine specific over-the-counter medications in relation to specific birth defects are necessary to better inform pregnant women about risks and safety. (c) 2005 Mosby, Inc. All rights reserved.