The relationship between major histocompatibility receptors and innate immunity in teleost fish
The relationship between major histocompatibility receptors and innate immunity in teleost fish
复制标题
DOI：
10.1016/s0145-305x(01)00030-1
复制
发表时间：
2001-10-01
影响因子：
2.9
通讯作者：
Stet, RJM
中科院分区：
文献类型：
--
作者：
Dixon, B;Stet, RJM
最近对先天免疫系统的研究表明，除了其在产生减缓病原体的初级反应中的作用外，它还可能在启动和指导适应性免疫系统产生的反应类型中发挥重要作用。这些发现显示了一个复杂的控制网络，包含先天免疫系统在组织T细胞对主要组织相容性受体呈递的抗原的反应中的新作用，以及这些受体在先天免疫反应中的新作用。这两种活动都是通过涉及先天和适应性免疫系统的反馈网络来管理的。本文将讨论这些新发现的相互作用，以及它们如何影响目前关于启动适应性免疫反应的理论。特别是，它将突出最近的进展，正在努力了解这些关系的硬骨鱼的免疫系统。(C)2001爱思唯尔科技有限公司版权所有。
Studies of the innate immune system have recently shown that, in addition to its role in producing the primary response that slows down pathogens, it may also play an important role in initiating and directing the type of response that the adaptive immune system makes. These discoveries have shown a complex web of control containing new roles for the innate immune system in organizing responses of T-cell to antigens being presented by major histocompatibility receptors, as well as new roles for those receptors in innate immune responses. Both of these activities are managed through feedback networks involving elements of both the innate and adaptive immune system. This paper will discuss these newly discovered interactions and how they are influencing current theories regarding the initiation of adaptive immune responses. In particular, it will highlight the recent progress that is being made towards understanding these relationships in the immune systems of teleost fish. (C) 2001 Elsevier Science Ltd. All rights reserved.