Electrochemical Detection and Quantification of Lithium Ions in Authentic Human Saliva Using LiMn2O4-modified Electrodes.
Electrochemical Detection and Quantification of Lithium Ions in Authentic Human Saliva Using LiMn2O4-modified Electrodes.
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DOI：
10.1021/acssensors.9b01176
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发表时间：
2019-08
期刊：
影响因子：
8.9
通讯作者：
A. Suherman;Bertold Rasche;B. Godlewska;Phil Nicholas;S. Herlihy;N. Caiger;P. Cowen;R. Compton
中科院分区：
文献类型：
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作者：
A. Suherman;Bertold Rasche;B. Godlewska;Phil Nicholas;S. Herlihy;N. Caiger;P. Cowen;R. Compton
我们报道了一种用于检测真实人唾液中锂离子（Li+）的锂锰氧化物（LiMn 2 O 4）修饰玻碳电极（LMO-GCE）和丝网印刷电极（LMO-SPE）电化学传感器。传感策略基于LMO的初始恒电流脱锂，然后通过线性溶出伏安法（LSV）检测分析物中的Li+。采用粉末X射线衍射（PXRD）和伏安法研究了该过程。LSV测量结果显示，LiClO 4水溶液和合成唾液样品中的可测量下限为50.0 µM，证明了所提出的分析方法适用于低Li+浓度。然后使用LMO-SPE用建立的传感策略分析了四种不同的真实人唾液样品，在高达5.0 mM Li+的浓度范围内显示出良好的线性，具有高重现性（RSD <7%），并适用于常规监测目的。分析样品所需的总时间小于3分钟。
We report an electrochemical sensor for the detection of lithium ions (Li+) in authentic human saliva at lithium manganese oxide (LiMn2O4)-modified glassy carbon electrodes (LMO-GCE) and screen-printed electrodes (LMO-SPE). The sensing strategy is based on an initial galvanostatic delithiation of LMO followed by linear stripping voltammetry (LSV) to detect Li+ in the analyte. The process was investigated using powder X-ray diffraction (PXRD) and voltammetry. LSV measurements reveal a measurable lower limit of 50.0 µM in both LiClO4 aqueous solutions and synthetic saliva samples, demonstrating the applicability of the proposed analytical method down to low Li+ concentrations. Four different samples of authentic human saliva were then analysed with the established sensing strategy using LMO-SPE, showing good linearity over a concentration range up to 5.0 mM Li+ with high reproducibility (RSD <7%) and applicability for routine monitoring purposes. The total time needed to analyse a sample is less than 3 min.