Lessons learned from the 1-hour post-load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised
Lessons learned from the 1-hour post-load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised
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DOI：
10.1002/dmrr.2992
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发表时间：
2018-07-01
影响因子：
8
通讯作者：
Dankner, Rachel
中科院分区：
文献类型：
--
作者：
Bergman, Michael;Jagannathan, Ram;Dankner, Rachel
这一观点涵盖了一个新的研究领域，描述了目前诊断血糖异常方法的不足之处，并提出75 g口服葡萄糖耐量试验期间1小时负荷后葡萄糖水平可作为一种新的生物标志物，比目前推荐的葡萄糖紊乱筛查标准更早地检测血糖异常。相当多的证据表明，负荷后1小时血糖值155 mg/dl（8.6 mmol/L）可以识别在进展为糖尿病前期和糖尿病之前具有细胞功能降低的个体，并且比HbA（1c）或负荷后2小时血糖值更容易预测那些可能进展为糖尿病的个体。在印度、日本、以色列和北欧人群中，负荷后1小时血糖水平升高比负荷后2小时血糖水平升高更能预测2型糖尿病。此外，流行病学研究表明，1小时PG 155 mg/dl（8.6 mmol/L）可预测糖尿病进展以及微血管疾病和死亡率风险增加，当2小时水平为
This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screening criteria for glucose disorders. Considerable evidence suggests that a 1-hour post-load plasma glucose value 155mg/dl (8.6mmol/L) may identify individuals with reduced -cell function prior to progressing to prediabetes and diabetes and is highly predictive of those likely to progress to diabetes more than the HbA(1c) or 2-hour post-load glucose values. An elevated 1-hour post-load glucose level was a better predictor of type 2 diabetes than isolated 2-hour post-load levels in Indian, Japanese, and Israeli and Nordic populations. Furthermore, epidemiological studies have shown that a 1-hour PG 155mg/dl (8.6mmol/L) predicted progression to diabetes as well as increased risk for microvascular disease and mortality when the 2-hour level was