Neurite degeneration elicited by apolipoprotein E peptides.
Neurite degeneration elicited by apolipoprotein E peptides.
复制标题
载脂蛋白 E 肽引起的神经突变性。
DOI：
10.1006/exnr.1994.1191
复制
发表时间：
1994
影响因子：
5.3
通讯作者：
Harmony,JA
中科院分区：
文献类型：
--
作者：
Crutcher,KA;Clay,MA;Scott,SA;Tian,X;Tolar,M;Harmony,JA
Apolipoprotein E (apoE) has been localized to the neurofibrillary tangles and β-amyloid-containing plaques found in the cortex of patients with Alzheimer's disease (AD) (14, 28), suggesting that apoE may play a role in this disorder. Recently, synthetic peptides containing a sequence within apoE (amino acids 141-155) were found to be cytotoxic to T lymphocytes in culture. In the present study, tandem presentation of the apoE sequence E141-155, as well as longer monomeric peptides that include this domain, was found to cause extensive and specific degeneration of neurites from embryonic chick sympathetic gangliain vitro. These results, together with the observation of strong βA4/apoE bindingin vitroand the disproportionate occurrence of the ϵ4 allele in both familial and sporadic AD patients, suggest that peptide sequences associated with apoE may contribute directly to neurodegenerative processes.
