CONFIRMATION OF CVS MOSAICISM IN TERM PLACENTAE AND HIGH-FREQUENCY OF INTRAUTERINE GROWTH-RETARDATION ASSOCIATION WITH CONFINED PLACENTAL MOSAICISM
CONFIRMATION OF CVS MOSAICISM IN TERM PLACENTAE AND HIGH-FREQUENCY OF INTRAUTERINE GROWTH-RETARDATION ASSOCIATION WITH CONFINED PLACENTAL MOSAICISM
复制标题
DOI：
10.1002/pd.1970111002
复制
发表时间：
1991-10-01
影响因子：
3
通讯作者：
WILSON, RD
中科院分区：
文献类型：
--
作者：
KALOUSEK, DK;HOWARDPEEBLES, PN;WILSON, RD
直接制备细胞滋养细胞或间充质基质培养后的绒毛标本中，约有2%的标本显示局限性胎盘嵌合体(CPM)，最常见的是染色体三体。据报告，在患有CPM的孕妇中，产前损失率(22%)以及胎儿生长迟缓(IUGR)的发生率明显更高。为了更准确地评估这些局限于胎盘的非整倍体细胞系对胎儿宫内生长和胎儿存活的影响，我们研究了34例经CVS诊断为CPM的足月胎盘，其中17例证实了相同的嵌合体。在CVS中出现大量的非整倍体细胞与在足月胎盘中检测到它们的可能性之间存在直接的相关性。此外，马赛克期胎盘中非整倍体细胞的比例与CVS标本中观察到的比例相关。在分娩时确诊为CPM的17例妊娠中，有6例宫内发育迟缓，5例为活产，1例与宫内死亡有关。
About 2 percent of specimens from chorionic villus sampling (CVS) analysed either on direct preparation of cytotrophoblast cells or after culture of mesenchymal stroma reveal confined placental mosaicism (CPM), most commonly involving chromosomal trisomy. A significantly higher rate of prenatal loss (22 per cent) as well as the presence of intrauterine growth retardation (IUGR) has been reported among pregnancies with CPM. To evaluate more precisely the effect of these aneuploid cell lines confined to the placenta on intrauterine fetal growth and fetal survival, we have studied 34 term placentae from pregnancies with CPM diagnosed on CVS and confirmed identical mosaicism in 17 of these placentae. There was a direct correlation between a high number of aneuploid cells present at CVS and a high likelihood of their detection in term placenta. Also, the proportion of aneuploid cells in the mosaic term placentae correlated with that observed in CVS specimens. Among 17 gestations with confirmed CPM at delivery, there were six cases of IUGR identified, five in liveborns and one associated with intrauterine death.