GENETIC-FACTORS IN THE ELECTROCARDIOGRAM AND HEART-RATE OF TWINS REARED APART AND TOGETHER
GENETIC-FACTORS IN THE ELECTROCARDIOGRAM AND HEART-RATE OF TWINS REARED APART AND TOGETHER
复制标题
DOI：
10.1016/0002-9149(89)90907-7
复制
发表时间：
1989-03-01
影响因子：
2.8
通讯作者：
RICH, S
中科院分区：
文献类型：
--
作者：
HANSON, B;TUNA, N;RICH, S
重要的生理机制被认为不会表现出大量的变异性，部分原因是假设关键的生物功能将进化到进化的最佳状态。要达到这一最佳状态，就必须消除这些变量的个体差异。使用的单卵双胞胎和双卵双胞胎的样本分开饲养，因为出生或婴儿早期，12导联心电图记录和心电向量图。从其他研究中获得的同卵双胞胎和异卵双胞胎一起饲养的这些变量的值。PR间期、QRS间期、QT间期和心室率变异的遗传和环境成分的最大似然检验表明遗传效应有显著贡献（大多数遗传力范围为30 - 60%），常见家族环境效应的贡献可忽略不计。
Important physiologic mechanisms have been thought not to exhibit large amounts of variability, due in part to the assumption that critical biologic functions will have evolved to an evolutionary optimum. The attainment of this optimum would necessary eliminate individual differences in these variables. Using a sample of monozygotic and dizygotic twins reared apart since birth or early infancy, 12-lead electrocardiographic recordings and vectorcardiograms were obtained. Values of these variables for monozygotic and dizygotic twins reared together were obtained from other studies. Maximum likelihood tests of genetic and environmental components of variation for PR interval, QRS duration, QT interval and ventricular rate indicated a significant contribution of genetic effects (most heritabilities ranged from 30 to 60%), with a negligible contribution from common familial environmental effects.