ASYMMETRIC SYNTHESIS OF 4-SUBSTITUTED 2,6-DIOXOPIPERIDINE-3-CARBONITRILE BY USING THIOUREA-CATALYZED ASYMMETRIC MICHAEL ADDITION
ASYMMETRIC SYNTHESIS OF 4-SUBSTITUTED 2,6-DIOXOPIPERIDINE-3-CARBONITRILE BY USING THIOUREA-CATALYZED ASYMMETRIC MICHAEL ADDITION
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DOI：
10.3987/com-08-s(d)18
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发表时间：
2009-04-01
期刊：
影响因子：
0.6
通讯作者：
Takemoto, Yoshiji
中科院分区：
文献类型：
--
作者：
Inokuma, Tsubasa;Nagamoto, Yuuki;Takemoto, Yoshiji
描述了在双功能硫脲的催化下，几种α，β-不饱和羰基化合物与丙二腈的对映选择性迈克尔加成反应。我们还证明了迈克尔加合物转化为对映体富集的官能化哌啶。
An enantioselective Michael addition of several alpha,beta-unsaturated carbonyl compounds with malononitrile catalyzed by a bifunctional thiourea is described. We also demonstrate the transformation of Michael adduct into an enantiomerically enriched functionalized piperidine.