Protein modules as organizers of membrane structure
Protein modules as organizers of membrane structure
复制标题
DOI：
10.1016/s0955-0674(99)80062-3
复制
发表时间：
1999-08-01
影响因子：
7.5
通讯作者：
Anderson, JM
中科院分区：
文献类型：
--
作者：
Fanning, AS;Anderson, JM
过去18个月进行的研究揭示了模块化蛋白质结合结构域，特别是PDZ结构域如何协调功能性质膜结构域的组装。MAGUK（膜相关鸟苷酸激酶）蛋白家族的成员，如PSD-95，使用多个结构域在突触、细胞连接和极化膜结构域聚集离子通道、受体、粘附分子和胞质信号蛋白。其他PDZ蛋白，如果蝇蛋白INAD和上皮Na+/H+调节因子（NHERF），通过将跨膜和胞质成分定位到特定的膜结构域并将这些成分组装成功能复合物来组织细胞信号传导。这些蛋白质组织成离散的结构对下游信号传导有功能影响。
Investigations conducted over the past 18 months have shed new light on how modular protein-binding domains, in particular PDZ domains, co-ordinate the assembly of functional plasma membrane domains. Members of the MAGUK (membrane-associated guanylate kinase) protein family, like PSD-95, use multiple domains to cluster ion channels, receptors, adhesion molecules and cytosolic signaling proteins at synapses, cellular junctions, and polarized membrane domains. Other PDZ proteins, like the Drosophila protein INAD and the epithelial Na+/H+ regulatory factor (NHERF), organize cellular signaling by localizing transmembrane and cytosolic components to specific membrane domains and assembling these components into functional complexes. The organization of these proteins into discreet structures has functional consequences for downstream signaling.